| Full text | |
| Author(s): Show less - |
Velthorst, Eva
[1, 2, 3]
;
Mollon, Josephine
[4]
;
Murray, Robin M.
[5]
;
de Haan, Lieuwe
[2, 6]
;
Germeys, Inez Myin
[7]
;
Glahn, David C.
[4]
;
Arango, Celso
[8]
;
van der Ven, Els
[9, 10]
;
Di Forti, Marta
[11, 12]
;
Bernardo, Miguel
[13]
;
Guloksuz, Sinan
[10, 14]
;
Delespaul, Philippe
[10, 15]
;
Mezquida, Gisela
[13]
;
Amoretti, Silvia
[13]
;
Bobes, Julio
[16]
;
Saiz, Pilar A.
[16]
;
Garcia-Portilla, Maria Paz
[16]
;
Santos, Jose Luis
[16, 17, 18]
;
Jimenez-Lopez, Estela
[19, 16]
;
Sanjuan, Julio
[20]
;
Aguilar, Eduardo J.
[20]
;
Arrojo, Manuel
[21]
;
Carracedo, Angel
[22, 23, 24]
;
Lopez, Gonzalo
[16]
;
Gonzalez-Penas, Javier
[16]
;
Parellada, Mara
[8]
;
Atbasoglu, Cem
[25]
;
Saka, Meram Can
[25]
;
Ucok, Alp
[26]
;
Alptekin, Koksal
[27, 28]
;
Akdede, Berna
[27]
;
Binbay, Tolga
[27]
;
Altinyazar, Vesile
[29]
;
Ulas, Halis
[27]
;
Yalincetin, Berna
[28]
;
Gumus-Akay, Guvem
[30, 31]
;
Beyaz, Burcin Cihan
[32]
;
Soygur, Haldun
[33]
;
Cankurtaran, Eylem Sahin
;
Kaymak, Semra Ulusoy
[34]
;
Maric, Nadja P.
[35, 36]
;
Mihaljevic, Marina M.
[35, 36]
;
Petrovic, Sanja Andric
[35, 37]
;
Mirjanic, Tijana
[38]
;
Del-Ben, Cristina Marta
[39]
;
Ferraro, Laura
[5]
;
Gayer-Anderson, Charlotte
[40]
;
Jones, Peter B.
[41]
;
Jongsma, Hannah E.
[41, 42]
;
Kirkbride, James B.
[42]
;
La Cascia, Caterina
[43]
;
Lasalvia, Antonio
[44]
;
Tosato, Sarah
[44]
;
Llorca, Pierre-Michel
[45]
;
Menezes, Paulo Rossi
[46]
;
Morgan, Craig
[40, 47]
;
Quattrone, Diego
[12]
;
Menchetti, Marco
[48]
;
Selten, Jean-Paul
[49, 10]
;
Szoke, Andrei
[50]
;
Tarricone, Ilaria
[51]
;
Tortelli, Andrea
[52]
;
McGuire, Philip
[5]
;
Valmaggia, Lucia
[53]
;
Kempton, Matthew J.
[5]
;
van der Gaag, Mark
[54]
;
Riecher-Rossler, Anita
[55]
;
Bressan, Rodrigo A.
[56]
;
Barrantes-Vidal, Neus
[57, 58]
;
Nelson, Barnaby
[59, 60]
;
McGorry, Patrick
[59, 61, 62]
;
Pantelis, Chris
[61, 62]
;
Krebs, Marie-Odile
[63]
;
Ruhrmann, Stephan
[64, 65]
;
Sachs, Gabriele
[66]
;
Rutten, Bart P. F.
[10]
;
van Os, Jim
[5, 10, 67]
;
Alizadeh, Behrooz Z.
[68, 69]
;
van Amelsvoort, Therese
[10]
;
Bartels-Velthuis, Agna A.
[69]
;
Bruggeman, Richard
[69, 70]
;
van Beveren, Nico J.
[71, 72, 73]
;
Luykx, Jurjen J.
[67, 74, 75]
;
Cahn, Wiepke
[67, 76]
;
Simons, Claudia J. P.
[10, 77]
;
Kahn, Rene S.
[1, 78]
;
Schirmbeck, Frederike
[2, 6]
;
van Winkel, Ruud
[10, 79]
;
Reichenberg, Abraham
[1, 3]
;
Study, EU-GEI High Risk
Total Authors: 90
|
| Affiliation: Show less - | [1] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 - USA
[2] Amsterdam UMC, Dept Psychiat, Amsterdam - Netherlands
[3] Icahn Sch Med Mt Sinai, Seaver Ctr Res & Treatment, New York, NY 10029 - USA
[4] Harvard Med Sch, Dept Psychiat, Boston Childrens Hosp, Boston, MA 02115 - USA
[5] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London - England
[6] Arkin Inst Mental Hlth, Amsterdam - Netherlands
[7] Katholieke Univ Leuven, Dept Neurosci, Psychiat Res Grp, Ctr Contextual Psychiat, Leuven - Belgium
[8] Univ Complutense, Spanish Mental Hlth Res Network CIBERSAM, Inst Psy, Inst Invest Sanitaria Gregorio Maranon IiSGM, Sch, Dept Child & Adolescent Psychiat, Hosp Gen Univ Gr, Madrid - Spain
[9] Columbia Univ, Mailman Sch Publ Hlth, New York, NY - USA
[10] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Med Ctr, Maastricht - Netherlands
[11] South London & Maudsley NHS Mental Hlth Fdn Trust, London - England
[12] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Social Genet & Dev Psychiat, London - England
[13] Univ Barcelona, Barcelona Clin Schizophrenia Unit, Spanish Mental Hlth Res Network CIBERSAM, Hosp Clin Barcelona, IDIBAPS, Neurosci Inst, Barcelona - Spain
[14] Yale Sch Med, Dept Psychiat, New Haven, CT - USA
[15] Mondriaan Mental Hlth Care, Heerlen Maastricht - Netherlands
[16] Univ Oviedo, Mental Hlth Serv Principado Asturias SESPA, Inst Invest Sanitaria Principado Asturias ISPA, Fac Med & Hlth Sci Psychiat, INEUROPA, CIBERSAM, Oviedo - Spain
[17] Univ Castilla La Mancha, Inst Technol, Neurobiol Res Grp, Cuenca - Spain
[18] Hosp Virgen Luz, Dept Psychiat, Cuenca - Spain
[19] Univ Castilla La Mancha, Hlth & Social Res Ctr, Cuenca - Spain
[20] Univ Valencia, Sch Med, Hosp Clin Univ Valencia, Dept Psychiat, INCLIVA, CIBERSAM, Valencia - Spain
[21] Complejo Hosp Univ Santiago de Compostela, Inst Invest Sanitaria IDIS, Dept Psychiat, Santiago De Compostela - Spain
[22] Galician Hlth Serv SERGAS, Inst Invest Sanitaria Santiago de Compostela IDIS, Grp Med Xen, Fdn Publ Galega Med Xen, Santiago De Compostela - Spain
[23] Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis CIMUS, Ctr Invest Red Enfermedades Raras CIBERER, Santiago De Compostela - Spain
[24] Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis CIMUS, Ctr Nacl Genotipado CEGEN PRB3, Santiago De Compostela - Spain
[25] Ankara Univ, Sch Med, Dept Psychiat, Ankara - Turkey
[26] Istanbul Univ, Dept Psychiat, Fac Med, Istanbul - Turkey
[27] Dokuz Eylul Univ, Sch Med, Dept Psychiat, Izmir - Turkey
[28] Dokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir - Turkey
[29] Adnan Menderes Univ, Sch Med, Dept Psychiat, Aydin - Turkey
[30] Ankara Univ, Sch Med, Dept Physiol, Ankara - Turkey
[31] Ankara Univ, Brain Res Ctr, Ankara - Turkey
[32] Middle East Tech Univ, Dept Psychol, Ankara - Turkey
[33] Turkish Federat Schizophrenia Assoc, Ankara - Turkey
[34] Ankara City Hosp, Psychiat Clin, Ankara - Turkey
[35] Univ Belgrade, Fac Med, Belgrade - Serbia
[36] Inst Mental Hlth, Belgrade - Serbia
[37] Clin Psychiat, Belgrade - Serbia
[38] Special Hosp Psychiat Disorders Kovin, Kovin - Serbia
[39] Univ Sao Paulo, Ribeirao Preto Med Sch, Sao Paulo - Brazil
[40] Kings Coll London, Inst Psychiat, Dept Hlth Serv & Populat Res, London - England
[41] Univ Cambridge, Dept Psychiat, Cambridge - England
[42] UCL, Div Psychiat, Psylife Grp, London - England
[43] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost, Palermo - Italy
[44] Univ Verona, Sect Psychiat, Dept Neurosci Biomed & Movement, Verona - Italy
[45] CHU Clermont Ferrand, Clermont Ferrand - France
[46] Univ Sao Paulo, Dept Prevent Med, Fac Med, Sao Paulo - Brazil
[47] Kings Coll London, ESRC Ctr Soc & Mental Hlth, London - England
[48] Univ Bologna, Dept Biomed & NeuroMotor Sci, Bologna - Italy
[49] Rivierduinen Inst Mental Hlth Care, Leiden - Netherlands
[50] INSERM, U955, Creteil - France
[51] Univ Bologna, Dept Med & Surg Sci, Psychiat Unit, Alma Mater Studiorum, Bologna - Italy
[52] Etab Publ Sante Maison Blanche, Paris - France
[53] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol, London - England
[54] Vrije Univ Amsterdam, Amsterdam Publ Mental Hlth Res Inst, Fac Behav & Movement Sci, Dept Clin Psychol, Amsterdam - Netherlands
[55] Univ Basel, Med Fak, Basel - Switzerland
[56] Univ Fed Sao Paulo UNIFESP, LiNC Lab Interdisciplinar Neurociencias Clin, Depto Psiquiatria, Escola Paulista Med, Sao Paulo - Brazil
[57] Univ Autonoma Barcelona, Dept Psicol Clin & Salut, Barcelona - Spain
[58] Fundacio Sanitaria Sant Pere Claver, Spanish Mental Hlth Res Network CIBERSAM, Barcelona - Spain
[59] Orygen, Parkville, Vic - Australia
[60] Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Vic - Australia
[61] Univ Melbourne, Melbourne Neuropsychiat Ctr, Dept Psychiat, Carlton, Vic - Australia
[62] Melbourne Hlth, Carlton, Vic - Australia
[63] Univ Paris, INSERM, GHU Paris, C JAAD, Inst Psychiat, CNRS 3557, U1266, Paris - France
[64] Univ Cologne, Fac Med, Dept Psychiat & Psychotherapy, Cologne - Germany
[65] Univ Cologne, Univ Hosp, Cologne - Germany
[66] Med Univ Vienna, Dept Psychiat & Psychotherapy, Vienna - Austria
[67] Univ Utrecht, Univ Med Ctr Utrecht, Dept Psychiat, Brain Ctr Rudolf Magnus, Utrecht - Netherlands
[68] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen - Netherlands
[69] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Rob Giel Res Ctr, Groningen - Netherlands
[70] Univ Groningen, Dept Clin & Dev Neuropsychol, Groningen - Netherlands
[71] Antes Ctr Mental Hlth Care, Rotterdam - Netherlands
[72] Erasmus MC, Dept Psychiat, Rotterdam - Netherlands
[73] Erasmus MC, Dept Neurosci, Rotterdam - Netherlands
[74] Univ Utrecht, Univ Med Ctr Utrecht, Dept Translat Neurosci, UMC Utrecht Brain Ctr, Utrecht - Netherlands
[75] GGNet Mental Hlth, Outpatient Opin Clin 2, Apeldoorn - Netherlands
[76] Altrecht Mental Hlth Care, Altrecht Sci, Utrecht - Netherlands
[77] GGzE Inst Mental Hlth Care, Eindhoven - Netherlands
[78] Educ & Clin Ctr MIRECC, James J Peters Dept Vet Affairs, VISN 2 Mental Illness Res, Med Ctr, New York, NY - USA
[79] Katholieke Univ Leuven, Dept Neurosci, Psychiat Res Grp, Ctr Clin Psychiat, Leuven - Belgium
Total Affiliations: 79
|
| Document type: | Journal article |
| Source: | MOLECULAR PSYCHIATRY; v. 26, n. 8, p. 4529-4543, AUG 2021. |
| Web of Science Citations: | 3 |
| Abstract | |
Important questions remain about the profile of cognitive impairment in psychotic disorders across adulthood and illness stages. The age-associated profile of familial impairments also remains unclear, as well as the effect of factors, such as symptoms, functioning, and medication. Using cross-sectional data from the EU-GEI and GROUP studies, comprising 8455 participants aged 18 to 65, we examined cognitive functioning across adulthood in patients with psychotic disorders (n = 2883), and their unaffected siblings (n = 2271), compared to controls (n = 3301). An abbreviated WAIS-III measured verbal knowledge, working memory, visuospatial processing, processing speed, and IQ. Patients showed medium to large deficits across all functions (ES range = -0.45 to -0.73, p < 0.001), while siblings showed small deficits on IQ, verbal knowledge, and working memory (ES = -0.14 to -0.33, p < 0.001). Magnitude of impairment was not associated with participant age, such that the size of impairment in older and younger patients did not significantly differ. However, first-episode patients performed worse than prodromal patients (ES range = -0.88 to -0.60, p < 0.001). Adjusting for cannabis use, symptom severity, and global functioning attenuated impairments in siblings, while deficits in patients remained statistically significant, albeit reduced by half (ES range = -0.13 to -0.38, p < 0.01). Antipsychotic medication also accounted for around half of the impairment in patients (ES range = -0.21 to -0.43, p < 0.01). Deficits in verbal knowledge, and working memory may specifically index familial, i.e., shared genetic and/or shared environmental, liability for psychotic disorders. Nevertheless, potentially modifiable illness-related factors account for a significant portion of the cognitive impairment in psychotic disorders. (AU) | |
| FAPESP's process: | 12/05178-0 - Schizophrenia and other psychotic disorders: social and biological determinants |
| Grantee: | Paulo Rossi Menezes |
| Support Opportunities: | Research Projects - Thematic Grants |