xosomes: Small vesicles with big roles in cancer, vaccine development, and therapeutic

Autor(es)

Thakur, Abhimanyu ^{[1, 2]} ; Parra, Diana Carolina ^[3] ; Motallebnejad, Pedram ^{[1, 2]} ; Brocchi, Marcelo ^[3] ; Chen, Huanhuan Joyce ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 - USA

^[2] Univ Chicago, Pritzker Sch Mol Engn, Chicago, IL 60637 - USA

^[3] Univ Campinas UNICAMP, Inst Biol, Dept Genet Evolut Microbiol & Immunol, Trop Dis Lab, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: IOACTIVE MATERIAL; v. 10, p. 281-294, APR 2022.
• Citações Web of Science: 1

Resumo

Cancer is a deadly disease that is globally and consistently one of the leading causes of mortality every year. Despite the availability of chemotherapy, radiotherapy, immunotherapy, and surgery, a cure for cancer has not been attained. Recently, exosomes have gained significant attention due to the therapeutic potential of their various components including proteins, lipids, nucleic acids, miRNAs, and lncRNAs. Exosomes constitute a set of tiny extracellular vesicles with an approximate diameter of 30-100 nm. They are released from different cells and are present in biofluids including blood, cerebrospinal fluid (CSF), and urine. They perform crucial multifaceted functions in the malignant progression of cancer via autocrine, paracrine, and endocrine communications. The ability of exosomes to carry different cargoes including drug and molecular information to recipient cells make them a novel tool for cancer therapeutics. In this review, we discuss the major components of exosomes and their role in cancer progression. We also review important literature about the potential role of exosomes as vaccines and delivery carriers in the context of cancer therapeutics. (AU)

• Processo FAPESP: 17/10051-2 - Potencial biotecnológico e caracterização fenotípica e molecular de mutantes de Salmonella enterica
• Beneficiário: Marcelo Brocchi
• Modalidade de apoio: Auxílio à Pesquisa - Regular