| Texto completo | |
| Autor(es): |
Pedroso, Renata Valle
[1]
;
Fraga, Francisco Jose
[2]
;
Crispim Nascimento, Carla Manuela
[1]
;
Pott-Junior, Henrique
[3]
;
Cominetti, Marcia Regina
[1]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Fed Univ Sao Carlos UFSCar, Dept Gerontol, Rod Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil
[2] Fed Univ ABC UFABC, Engn Modelling & Appl Social Sci Ctr CECS, Santo Andre, SP - Brazil
[3] Fed Univ Sao Carlos UFSCar, Dept Med, Rod Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Behavioural Brain Research; v. 420, FEB 26 2022. |
| Citações Web of Science: | 0 |
| Resumo | |
Aim: To investigate the influence of apolipoprotein E (APOE) genotype on cortical activity, using the event-related potential P300 in healthy older adults and individuals with Alzheimer's disease (AD). Methods: A cohort of 37 healthy older adults and 48 with AD participated in this study and completed an auditory oddball task using electroencephalographic equipment with 21 channels (10-20 system). APOE genotyping was obtained by real-time PCR. Results: AD presented increased P300 latency and lower P300 amplitude, compared to healthy older adults. AD APOE epsilon 4 carriers presented increased P300 latency in F3 (420.7 +/- 65.8 ms), F4 (412.0 +/- 49.0 ms), C4 (413.0 +/- 41.1 ms) and P3 (420.4 +/- 55.7 ms) compared to non-carriers (F3 = 382.5 +/- 56.8 ms, p < 0.01; F4 = 372.2 +/- 56.7 ms, p < 0.01; C4 = 374.2 +/- 51.7 ms, p < 0.01; P3 = 384.4 +/- 44.4 ms, p < 0.01). Healthy older adults APOE epsilon 4 carriers presented lower Fz amplitude (2.6 +/- 1.5 mu V) compared to non-carriers (4.9 +/- 2.9 mu V; p = 0.02). Linear regression analysis showed that being a carrier of APOE epsilon 4 allele remained significantly associated with P300 latency even after adjusting for sex, age, and cognitive grouping. APOE epsilon 4 allele increases P300 latency (95% CI 0.11-0.98; p = 0.02). Conclusion: APOE epsilon 4 allele negatively impacts cortical activity in both healthy older adults and AD individuals. (AU) | |
| Processo FAPESP: | 19/02648-4 - Papel de proteínas da via de sinalização da insulina e sua relação com a secretase ADAM10 na doença de Alzheimer |
| Beneficiário: | Márcia Regina Cominetti |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/18808-5 - Influência do genótipo da apolipoproteína e (apoe) e de fatores neurotróficos nos potenciais evocados (erp-p300) de idosos com doença de alzheimer e idosos saudáveis |
| Beneficiário: | Renata Valle Pedroso |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |