polipoprotein E epsilon 4 allele impairs cortical activity in healthy aging and Alzheimer's diseas

Author(s)

Pedroso, Renata Valle ^[1] ; Fraga, Francisco Jose ^[2] ; Crispim Nascimento, Carla Manuela ^[1] ; Pott-Junior, Henrique ^[3] ; Cominetti, Marcia Regina ^[1]

Affiliation

^[1] Fed Univ Sao Carlos UFSCar, Dept Gerontol, Rod Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil

^[2] Fed Univ ABC UFABC, Engn Modelling & Appl Social Sci Ctr CECS, Santo Andre, SP - Brazil

^[3] Fed Univ Sao Carlos UFSCar, Dept Med, Rod Washington Luis, Km 235, BR-13565905 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: Behavioural Brain Research; v. 420, FEB 26 2022.
• Web of Science Citations: 0

Abstract

Aim: To investigate the influence of apolipoprotein E (APOE) genotype on cortical activity, using the event-related potential P300 in healthy older adults and individuals with Alzheimer's disease (AD). Methods: A cohort of 37 healthy older adults and 48 with AD participated in this study and completed an auditory oddball task using electroencephalographic equipment with 21 channels (10-20 system). APOE genotyping was obtained by real-time PCR. Results: AD presented increased P300 latency and lower P300 amplitude, compared to healthy older adults. AD APOE epsilon 4 carriers presented increased P300 latency in F3 (420.7 +/- 65.8 ms), F4 (412.0 +/- 49.0 ms), C4 (413.0 +/- 41.1 ms) and P3 (420.4 +/- 55.7 ms) compared to non-carriers (F3 = 382.5 +/- 56.8 ms, p < 0.01; F4 = 372.2 +/- 56.7 ms, p < 0.01; C4 = 374.2 +/- 51.7 ms, p < 0.01; P3 = 384.4 +/- 44.4 ms, p < 0.01). Healthy older adults APOE epsilon 4 carriers presented lower Fz amplitude (2.6 +/- 1.5 mu V) compared to non-carriers (4.9 +/- 2.9 mu V; p = 0.02). Linear regression analysis showed that being a carrier of APOE epsilon 4 allele remained significantly associated with P300 latency even after adjusting for sex, age, and cognitive grouping. APOE epsilon 4 allele increases P300 latency (95% CI 0.11-0.98; p = 0.02). Conclusion: APOE epsilon 4 allele negatively impacts cortical activity in both healthy older adults and AD individuals. (AU)

• FAPESP's process: 19/02648-4 - Role of the insulin signaling pathway proteins and their relation with the secretase ADAM10 in Alzheimer's Disease
• Grantee: Márcia Regina Cominetti
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/18808-5 - Influence of APOE genotype and neurotrophic factors on event related potentials (ERP-P300) of elderly with Alzheimer's Disease and healthy elderly
• Grantee: Renata Valle Pedroso
• Support Opportunities: Scholarships in Brazil - Post-Doctoral