an Non-invasive Ventilation Modulate Cerebral, Respiratory, and Peripheral Muscle Oxygenation During High-Intensity Exercise in Patients With COPD-HF

Autor(es)

Goulart, Cassia da Luz ^[1] ; Caruso, Flavia Rossi ^[1] ; de Araujo, Adriana Sanches Garcia ^[1] ; Moura, Silvia Cristina Garcia de ^[2] ; Catai, Aparecida Maria ^[2] ; Agostoni, Piergiuseppe ^[3] ; Mendes, Renata Goncalves ^[1] ; Arena, Ross ^[4] ; Borghi-Silva, Audrey ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Carlos UFSCar, Cardiopulm Physiotherapy Lab, Physiotherapy Dept, Sao Carlos - Brazil

^[2] Univ Fed Sao Carlos, Physiotherapy Dept, Cardiovasc Phys Therapy Lab, Sao Carlos - Brazil

^[3] Univ Milan, Ctr Cardiol Monzino, Dept Clin Sci & Community Hlth, Cardiovasc Sect, Milan - Italy

^[4] Univ Illinois, Coll Appl Hlth Sci, Dept Phys Therapy, Chicago, IL - USA

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN CARDIOVASCULAR MEDICINE; v. 8, JAN 31 2022.
• Citações Web of Science: 0

Resumo

Aim: To evaluate the effect of non-invasive positive pressure ventilation (NIPPV) on (1) metabolic, ventilatory, and hemodynamic responses; and (2) cerebral (Cox), respiratory, and peripheral oxygenation when compared with SHAM ventilation during the high-intensity exercise in patients with coexisting chronic obstructive pulmonary disease (COPD) and heart failure (HF).\& nbsp;Methods and Results: On separate days, patients performed incremental cardiopulmonary exercise testing and two constant-work rate tests receiving NIPPV or controlled ventilation (SHAM) (the bilevel mode-Astral 150) in random order until the limit of tolerance (Tlim). During exercise, oxyhemoglobin (OxyHb+Mb) and deoxyhemoglobin (DeoxyHb+Mb) were assessed using near-infrared spectroscopy (Oxymon, Artinis Medical Systems, Einsteinweg, The Netherlands). NIPPV associated with high-intensity exercise caused a significant increase in exercise tolerance, peak oxygen consumption (V \& BULL;O2 in mlO(2)\& BULL;kg(-1)\& BULL;min(-1)), minute ventilation peak (V \& BULL;E in ml/min), peak peripheral oxygen saturation (SpO(2), %), and lactate/tlim (mmol/s) when compared with SHAM ventilation. In cerebral, respiratory, and peripheral muscles, NIPPV resulted in a lower drop in OxyHb+Mb (p < 0.05) and an improved deoxygenation response DeoxyHb+Mb (p < 0.05) from the half of the test (60% of Tlim) when compared with SHAM ventilation.\& nbsp;Conclusion: Non-invasive positive pressure ventilation during constant work-rate exercise led to providing the respiratory muscle unloading with greater oxygen supply to the peripheral muscles, reducing muscle fatigue, and sustaining longer exercise time in patients with COPD-HF. (AU)

• Processo FAPESP: 20/13465-5 - Identificação de variáveis prognósticas do teste de exercício cardiopulmonar para estratificar gravidade da insuficiência cardíaca
• Beneficiário: Cássia da Luz Goulart
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Doutorado Direto
• Processo FAPESP: 18/03233-0 - Estudo da interação cardiorrespiratória e da oferta de oxigênio periférica e cerebral como moduladores da capacidade de exercício durante a aplicação do binível na coexistência da DPOC-ICC
• Beneficiário: Cássia da Luz Goulart
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto