ffect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matter

Autor(es):Mostrar menos -

Crippa, Jose A. ^{[1, 2]} ; Junior, Luiz C. Pereira ^[3] ; Pereira, Livia C. ^[1] ; Zimmermann, Patricia M. ^[4] ; Brum Junior, Liberato ^[4] ; Rechia, Leticia M. ^[4] ; Dias, Isabella ^[1] ; Hallak, Jaime E. ^{[1, 2]} ; Campos, Alline C. ^{[5, 1]} ; Guimaraes, Francisco S. ^{[5, 1]} ; Queiroz, Regina H. ^{[3, 2]} ; Zuardi, Antonio W. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Ribeirao Preto FMRP, Dept Neurociencias & Ciencias Comportamento, Av Bandeirantes, 3900, 3 Andar, BR-14049900 Ribeirao Preto, SP - Brazil

^[2] Conselho Nacl Desenvolvimento Cient & Tecnol CNPq, Inst Nacl Ciencia & Tecnol Med Translac INCT TM, Ribeirao Preto, SP - Brazil

^[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Analises Clin Toxicol & Bromatol, Ribeirao Preto, SP - Brazil

^[4] Prati Donaduzzi, Toledo, PR - Brazil

^[5] Univ Sao Paulo, FMRP, Dept Farmacol, Ribeirao Preto, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Revista Brasileira de Psiquiatria; v. 44, n. 1, p. 15-20, JAN-FEB 2022.
• Citações Web of Science: 1

Resumo

Objective: To compare plasma concentrations of cannabidiol (CBD) following oral administration of two formulations of the drug (powder and dissolved in oil), and to evaluate the effects of these distinct formulations on responses to emotional stimuli in healthy human volunteers. Methods: In a randomized, double-blind, placebo-controlled, parallel-group design, 45 healthy male volunteers were randomly assigned to three groups of 15 subjects that received either 150 mg of CBD powder; 150 mg of CBD dissolved in corn oil; or placebo. Blood samples were collected at different times after administration, and a facial emotion recognition task was completed after 150 min. Results: There were no significant differences across groups in the subjective and physiological measures, nor in the facial emotion recognition task. However, groups that received the drug showed statistically significant differences in baseline measures of plasma CBD, with a significantly greater difference in favor of the oil formulation. Conclusion: When administered as a single 150-mg dose, neither formulation of oral CBD altered responses to emotional stimuli in healthy subjects. The oil-based CBD formulation resulted in more rapid achievement of peak plasma level, with an approximate fourfold increase in oral bioavailability. (AU)

• Processo FAPESP: 08/09009-2 - Uso crônico de crack: densidade de transportador de dopamina, fatores genéticos e funcionamento executivo
• Beneficiário: Acioly Luiz Tavares de Lacerda
• Modalidade de apoio: Auxílio à Pesquisa - Regular