Effect of nonsteroidal anti-inflammatory drugs (NSAIDs) association on physicochemical and biological properties of tricalcium silicate-based cement

Autor(es)

Maria Carolina Guiotti de Oliveira ^[1] ; Índia Olinta de Azevedo Queiroz ^[2] ; Thiago Machado ^[3] ; Lorena de Mello Alcântara Garrido ^[4] ; Sandra Helena Penha de Oliveira ^[5] ; Marco Antonio Hungaro Duarte ^[6]

Afiliação do(s) autor(es)

^[1] USP. Bauru School of Dentistry. Department of Dentistry, Endodontics and Dental Materials - Brasil

^[2] USP. Bauru School of Dentistry. Department of Dentistry, Endodontics and Dental Materials - Brasil

^[3] UNESP. Araçatuba Dental School. Department of Oral and Maxillofacial Surgery and Integrated Clinic - Brasil

^[4] USP. Bauru School of Dentistry. Department of Dentistry, Endodontics and Dental Materials - Brasil

^[5] UNESP. Araçatuba Dental School. Department of Basic Science - Brasil

^[6] USP. Bauru School of Dentistry. Department of Dentistry, Endodontics and Dental Materials - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Dental Journal; v. 33, n. 3, p. 47-54, 2022-06-24.

Resumo

Abstract The aim of this study was to investigate the physicochemical and biological properties of an experimental tricalcium silicate-based repair cement containing diclofenac sodium (CERD). For the physicochemical test, MTA, Biodentine and CERD were mixed and cement disc were prepared to evaluate the setting time and radiopacity. Root-end cavity were performed in acrylic teeth and filled with cements to analyze the solubility up to 7 days. Polyethylene tubes containing cements were prepared and calcium ions and pH were measured at 3h, 24h, 72h and 15 days. For the biological test, SAOS-2 were cultivated, exposed to cements extracts and cell proliferation were investigated by MTT assay at 6h, 24h and 48h. Polyethylene tubes containing cements were implanted into Wistar rats. After 7 and 30 days, the tubes were removed and processed for histological analyses. Parametric and nonparametric data were performed. No difference was identified in relation to setting time, radiopacity and solubility. Biodentine released more calcium ion than MTA and CERD; however, no difference between MTA and CERD were detected. Alkaline pH was observed for all cements and Biodentine exhibited highest pH. All cements promoted a raise on cell proliferation at 24h and 48h, except CERD at 48h. Biodentine stimulated cell metabolism in relation to MTA and CERD while CERD was more cytotoxic than MTA at 48h. Besides, no difference on both inflammatory response and mineralization ability for all cement were found. CERD demonstrated similar proprieties to others endodontic cements available. (AU)

• Processo FAPESP: 18/20676-2 - Avaliação de propriedades físico-químicas de cimentos experimentais reparadores à base de silicato tricálcio
• Beneficiário: Maria Carolina Guiotti de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica