Autor(es)

Oliveira, Luciana da Costa ; Morais, Gustavo Paroschi ; Ropelle, Eduardo R. ; de Moura, Leandro P. ; Cintra, Dennys E. ; Pauli, Jose R. ; de Freitas, Ellen C. ; Rorato, Rodrigo ; da Silva, Adelino Sanchez R.

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN NUTRITION; v. 9, p. 15-pg., 2022-03-30.

Resumo

Intermittent fasting (IF) is a popular intervention used to fight overweight/obesity. This condition is accompanied by hypothalamic inflammation, limiting the proper signaling of molecular pathways, with consequent dysregulation of food intake and energy homeostasis. This mini-review explored the therapeutic modulation potential of IF regarding the disruption of these molecular pathways. IF seems to modulate inflammatory pathways in the brain, which may also be correlated with the brain-microbiota axis, improving hypothalamic signaling of leptin and insulin, and inducing the autophagic pathway in hypothalamic neurons, contributing to weight loss in obesity. Evidence also suggests that when an IF protocol is performed without respecting the circadian cycle, it can lead to dysregulation in the expression of circadian cycle regulatory genes, with potential health damage. In conclusion, IF may have the potential to be an adjuvant treatment to improve the reestablishment of hypothalamic responses in obesity. (AU)

• Processo FAPESP: 17/25492-4 - Efeitos da combinação do jejum intermitente com o exercício físico sobre a via autofágica hipotalâmica em camundongos obesos
• Beneficiário: Luciana da Costa Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 20/08192-0 - Respostas da via da autofagia no hipotálamo de camundongos obesos submetidos ao jejum intermitente associado ao treinamento físico
• Beneficiário: Adelino Sanchez Ramos da Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular