Photodynamic therapy associated with nanomedicine strategies for treatment of human squamous cell carcinoma: A systematic review and meta-analysis

Autor(es)

Ferrisse, Tulio Morandin ; de Oliveira, Analu Barros ; Surur, Amanda Koberstain ; Buzo, Helen Sordi ; Brighenti, Fernanda Lourencao ; Fontana, Carla Raquel

• Tipo de documento: Artigo Científico
• Fonte: Nanomedicine-Nanotechnology Biology and Medicine; v. 40, p. 10-pg., 2022-02-01.

Resumo

A systematic review and meta-analysis were conducted about photodynamic therapy (PDT) associated with nanomedicine approaches in the treatment of human squamous cell carcinoma (HSSC). Independent reviewers conducted all steps in the systematic review. For evaluating the risk of bias, RoB 2, OHAT and SYRCLE tools were used. Meta-analysis was performed using a random-effect model (alpha = 0.05). For PDT against HSSC, Protoporphyrin IX was the photosensitizer, and liposomes were the nanomaterial more frequently used. Photosensitizers conjugated with nanoparticles exhibited positive results against HSSC. Tumors treated with PDT in combination with a nanotechnology drug-delivery system had an increased capacity for inhibiting the tumor growth rate (51.93%/P < 0.0001) when compared with PDT only. Thus, the PDT associated with nanomedicine approaches against HSCC could be a significant option for use in future clinical studies, particularly due to improved results in tumor growth inhibition. (C) 2021 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 18/23015-7 - Terapia fotodinâmica antimicrobiana via irradiação em modo contínuo e chaveado contra Enterococcus faecalis e Cutibacterium acnes
• Beneficiário: Carla Raquel Fontana
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 20/05169-7 - Estudo da aplicação de extratos vegetais de Senna spp. como fotossensibilizadores em terapia fotodinâmica antimicrobiana contra espécies de Candida
• Beneficiário: Helen Sordi Buzo
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 21/01191-0 - Indução de tolerância e caracterização do biofime de Candida albicans submetido à terapia fotodinâmica antimicrobiana
• Beneficiário: Túlio Morandin Ferrisse
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado