Pharmacological Approaches to the Treatment of Dementia in Down Syndrome: A Systematic Review of Randomized Clinical Studies

Autor(es)

de Oliveira, Laura Cavalcanti ; de Paula Faria, Daniele

• Tipo de documento: Artigo Científico
• Fonte: Molecules; v. 27, n. 10, p. 11-pg., 2022-05-01.

Resumo

Down Syndrome (DS) is considered the most frequent form of Intellectual Disability, with important expressions of cognitive decline and early dementia. Studies on potential treatments for dementia in this population are still scarce. Thus, the current review aims to synthesize the different pharmacological approaches that already exist in the literature, which focus on improving the set of symptoms related to dementia in people with DS. A total of six studies were included, evaluating the application of supplemental antioxidant therapies, such as alpha-tocopherol; the use of acetylcholinesterase inhibitor drugs, such as donepezil; N-methyl-d-aspartate (NMDA) receptor antagonists, such as memantine; and the use of vitamin E and a fast-acting intranasal insulin. Two studies observed important positive changes related to some general functions in people with DS (referring to donepezil). In the majority of studies, the use of pharmacological therapies did not lead to improvement in the set of symptoms related to dementia, such as memory and general functionality, in the population with DS. (AU)

• Processo FAPESP: 18/15167-1 - Neuroimagem translacional na deficiência intelectual: avaliação de alterações moleculares associadas ao envelhecimento na Síndrome de Down
• Beneficiário: Daniele de Paula Faria
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 20/11728-9 - Imagem PET para avaliação de neuroinflamação no envelhecimento de pessoas com Síndrome de Down
• Beneficiário: Laura Cavalcanti de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Mestrado