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(Referência obtida automaticamente do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Chemical study of Adenocalymma axillarum crude leaf extract and isolated compounds

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Autor(es):
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João Paulo Campos Andrade [1] ; Osvaine Junior Alvarenga Alves [2] ; Marian Caroline Costa [3] ; Valéria Maria Melleiro Gimenez [4] ; Iara Silva Squarisi [5] ; Heloiza Diniz Nicolella [6] ; Mariana Cintra Pagotti [7] ; Denise Crispim Tavares [8] ; Wilson Roberto Cunha [9] ; Márcio Luís Andrade e Silva [10] ; Ana Helena Januario [11] ; Lizandra Guidi Magalhães [12] ; Patrícia Mendonça Pauletti [13]
Número total de Autores: 13
Afiliação do(s) autor(es):
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[1] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[2] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[3] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[4] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[5] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[6] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[7] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[8] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[9] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[10] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[11] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[12] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[13] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
Número total de Afiliações: 13
Tipo de documento: Artigo Científico
Fonte: Brazilian Journal of Pharmaceutical Sciences; v. 58, 2020-11-14.
Resumo

Abstract Adenocalymma axillarum (K.Schum.) L.G. Lohmann is a liana belonging to the family Bignoniaceae. In traditional medicine, the genus Adenocalymma is used to treat fever, skin ailments, and body, joint, and facial muscle pains, and it is also applied as cosmetic. Biological assays conducted with the A. axillarum crude leaf ethanol extract have indicated leishmanicidal activity and absence of cytotoxicity. This study aimed to analyze the A. axillarum leaf ethanol crude extract by high-performance liquid chromatography-high-resolution mass spectrometry- diode array detector (HPLC-HRMS-DAD) and to evaluate the leishmanicidal and cytotoxic activities of this crude extract, its fractions, and isolated compounds. HPLC-HRMS-DAD analysis of this extract revealed that it consisted mainly of flavonoids, with nine major compounds. Extract purification yielded 4-hydroxy-N-methylproline, 6-β-hydroxyipolamiide, quercetin-3-O-robinobioside, hyperin, isorhamnetin-3-O-robinobioside, and 3’-O-methylhyperin, which were identified by Nuclear Magnetic Resonance. The isolated compounds were inactive against Leishmania amazonensis promastigotes and human lung fibroblast cells. (AU)

Processo FAPESP: 17/24860-0 - Avaliação da toxicidade aguda in vivo do extrato etanólico das folhas de Stizophyllum perforatum e estudo químico associado à avaliação das atividades antiparasitária e citotóxica in vitro
Beneficiário:Osvaine Junior Alvarenga Alves
Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 16/10313-4 - Estudo fitoquímico e avaliação das atividades esquistossomicida, citotóxica e leishmanicida de plantas do cerrado
Beneficiário:Patricia Mendonça Pauletti
Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Regular