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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chemical study of Adenocalymma axillarum crude leaf extract and isolated compounds

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Author(s):
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João Paulo Campos Andrade [1] ; Osvaine Junior Alvarenga Alves [2] ; Marian Caroline Costa [3] ; Valéria Maria Melleiro Gimenez [4] ; Iara Silva Squarisi [5] ; Heloiza Diniz Nicolella [6] ; Mariana Cintra Pagotti [7] ; Denise Crispim Tavares [8] ; Wilson Roberto Cunha [9] ; Márcio Luís Andrade e Silva [10] ; Ana Helena Januario [11] ; Lizandra Guidi Magalhães [12] ; Patrícia Mendonça Pauletti [13]
Total Authors: 13
Affiliation:
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[1] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[2] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[3] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[4] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[5] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[6] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[7] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[8] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[9] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[10] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[11] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[12] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
[13] University of Franca. Center for Research in Exact and Technological Sciences - Brasil
Total Affiliations: 13
Document type: Journal article
Source: Brazilian Journal of Pharmaceutical Sciences; v. 58, 2020-11-14.
Abstract

Abstract Adenocalymma axillarum (K.Schum.) L.G. Lohmann is a liana belonging to the family Bignoniaceae. In traditional medicine, the genus Adenocalymma is used to treat fever, skin ailments, and body, joint, and facial muscle pains, and it is also applied as cosmetic. Biological assays conducted with the A. axillarum crude leaf ethanol extract have indicated leishmanicidal activity and absence of cytotoxicity. This study aimed to analyze the A. axillarum leaf ethanol crude extract by high-performance liquid chromatography-high-resolution mass spectrometry- diode array detector (HPLC-HRMS-DAD) and to evaluate the leishmanicidal and cytotoxic activities of this crude extract, its fractions, and isolated compounds. HPLC-HRMS-DAD analysis of this extract revealed that it consisted mainly of flavonoids, with nine major compounds. Extract purification yielded 4-hydroxy-N-methylproline, 6-β-hydroxyipolamiide, quercetin-3-O-robinobioside, hyperin, isorhamnetin-3-O-robinobioside, and 3’-O-methylhyperin, which were identified by Nuclear Magnetic Resonance. The isolated compounds were inactive against Leishmania amazonensis promastigotes and human lung fibroblast cells. (AU)

FAPESP's process: 16/10313-4 - Phytochemistry study and evaluation of the schistosomicidal, cytotoxicity and leishmanicidal activities from cerrado plants
Grantee:Patricia Mendonça Pauletti
Support Opportunities: BIOTA-FAPESP Program - Regular Research Grants
FAPESP's process: 17/24860-0 - Acute toxicity evaluation of Stizophyllum perforatum leaves crude ethanol extract in vivo and chemical study associated with the evaluation of antiparasitic and cytotoxic activities in vitro
Grantee:Osvaine Junior Alvarenga Alves
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)