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Chemical and pharmacological validation of extracts and active compounds of Copaifera species

Grant number: 11/13630-7
Support type:Research Projects - Thematic Grants
Duration: April 01, 2012 - March 31, 2017
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Jairo Kenupp Bastos
Grantee:Jairo Kenupp Bastos
Home Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Principal researchers:Lizandra Guidi Magalhães
Assoc. researchers:Antônio Eduardo Miller Crotti ; Carlos Henrique Gomes Martins ; Claudia Helena Pellizzon ; Denise Crispim Tavares Barbosa ; Hervé Louis Ghislain Rogez ; José Maurício Sforcin ; Luis Alexandre Pedro de Freitas ; Luiz Alberto Beraldo de Moraes ; Márcio Luís Andrade e Silva ; Niege Araçari Jacometti Cardoso Furtado ; Raquel Alves dos Santos ; Rodrigo Cassio Sola Veneziani ; Sergio Akira Uyemura ; Sergio Ricardo Ambrosio ; Vanderlei Rodrigues ; Vera Lúcia Lanchote ; Vladimir Constantino Gomes Heleno ; Wilson Roberto Cunha
Associated grant(s):14/04464-4 - 55th Annual Meeting of the American Society of Pharmacognosy & 14th Annual Oxford International Conference on the Science of Botanicals, AR.EXT
Associated scholarship(s):17/02592-3 - Biotransformation of cubebin and hardwickiic acid by Cunninghamella echinulata and biological activities evaluation, BP.MS
16/20589-7 - Copaifera lucens: antibacterial action of the hydroalcoholic crude extract and the oleoresin against oral pathogens and its cytotoxic and genotoxic potential, BP.IC
15/23154-9 - Histological analysis of the cicatrization in chemical ulcers after treatment the copaiba oil (Copaifera Hayne multijuga), with concentration of the 3%, BP.IC
+ associated scholarships 15/17641-4 - Histological evaluation of the effect of copaiba oil (Copaifera multijuga Hayne) at a concentration of 1% on the healing of corneal ulcers caused by chemical burns in rats, BP.IC
16/07075-4 - In vitro susceptibility of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans against oleoresin and compounds isolated from species of Copaifera spp, BP.IC
16/01232-0 - Copaifera oleoresins: development and validation of a HPLC-DAD analytical method and phytochemical study and in vitro antitumor evaluation of the main secondary metabolites obtained, BP.DD
15/12372-5 - Potential study cytotoxic and genotoxic of Copaifera lucens extract cells of mammals in vitro and in vivo, BP.IC
15/19714-9 - A preliminary investigation of the anti-Helicobacter pylori by some Copaifera spp. species, BP.IC
14/23684-5 - Evaluation of cellular and molecular mechanisms in skin wound healing using Copaifera langsdorffii hydroalcoholic extract and oil resin ointments, BP.MS
15/05954-8 - Potential antigenotoxic and against poisoning by mercury and lead of flavonoids and galloylquinic compounds from Copaifera langsdorffii Desf, BP.MS
14/13094-6 - Evaluation of cell death induction by Copaifera duckei oleoresin and polyaltic acid in MCF-7 cell line, BP.IC
14/09528-0 - BIOACTIVITY ANALYSIS OF CRUDE HYDROALCOHOLIC EXTRACT OF LEAVES AND OLEORESIN OF COPAIFERA MULTIJUGA AGAINST ORAL PATHOGENS, BP.IC
14/03092-6 - Chemical validation and in vitro antitumor activity of secondary metabolites obtained from the oleoresin of Copaifera multijuga, BP.MS
13/19488-3 - EVALUATION IN VIVO AND IN VITRO OF CHEMOPREVENTIVE POTENTIAL OF OIL-RESIN Copaifera reticulata Ducke: PARAMETERS GENOTOXIC BIOCHEMICAL AND IMMUNOHISTOCHEMICAL, BP.PD
13/21167-0 - Antiparasitary potential evaluation for a group of labdane diterpenes against Leishmania amazonensis., BP.IC
12/24856-9 - Copaifera duckei Dwyer: EVALUATION OF ANTIBACTERIAL POTENTIAL AGAINST BUCCAL PATHOGENS AND CYTOTOXICITY, BP.MS
13/06591-0 - Chemical study of the hydroalcoholic extract of the leaves of Copaifera oblongifolia and antiparasitic assays., BP.IC
12/22832-5 - Fragmentation studies on labdane-type diterpenes isolated from Copaifera langsdorfii oleoresin using tandem mass spectrometry, BP.MS
12/24200-6 - In vitro antitumor activity of secondary metabolites obtained from the oleoresin of Copaifera duckei, BP.IC
12/15092-5 - This project is integrant of CHEMICAL AND PHARMACOLOGICAL VALIDATION OF EXTRACTS AND ACTIVE COMPOUNDS OF COPAIFERA SPECIES FAPESP 2011/13630-7., BP.IC
12/12881-9 - Antibacterial activity of the crude extract and derivatives from Copaifera langsdorffii against planktonic and sessile anaerobic bacteria, BP.IC
12/02082-1 - Copaifera langsdorffii: development of liposomes stabilized by spray freeze drying with selective antitumor action., BP.DR
12/08335-9 - STUDY ANTIBACTERIAL, MUTAGENIC AND CYTOTOXIC POTENTIAL OF HYDROALCOHOLIC EXTRACT CRUDE FROM COPAIFERA TRAPEZIFOLIA, BP.MS - associated scholarships

Abstract

Despite the wide folk use of copaiba oil resin by the Brazilians since XIX century, the several studies corroborating many of its ethnopharmacological uses, and its production being around 800 tons per year, there is a great need of undertaking phytochemical, pharmacological, toxicological and clinical studies, aiming to guarantee the safety, efficacy and quality, which are mandatory for developing new phytomedicines. It should be pointed out that the majority of the reported data are related to the crude oil resin and there are few studies on the aerial parts of Copaifera plants. Therefore, the goal of this proposal is to undertake a wide study with eight species of Copaifera, such as: C. duckei Dwyer, C. martii Hayne, C. reticulata Ducke, C. multijuga Hayne e C. piresii Ducke, C. langsdorffii Desff, C. trapezifolia Hayne e C. officinalis (Jacq.) L, aiming to undertake the chemical and pharmacological validation, as well as the standardization of these plants extracts to establish the bases for the development of new medicines. For that, a multidisciplinary team will undertake the following: metabolomic study of the oil resins and the leaf extracts for the isolation and identification of the major secondary metabolites, to be used as chromatographic standards and in the biological assays; development of analytical methods and desreplication studies to guide both the phytochemical and seasonal studies; investigation of the anti-inflammatory, analgesic, immunomodulatory, wound healing, antimicrobial, antiparasitical and antitumor activities for the crude extracts and major isolated compounds; determination of both in vitro and in vivo toxicological parameters; studies of biotransformation by the gut bacteria; pharmacokinetic studies of the selected extracts and isolated compounds, as well as the use of spray drier technique to produce standardized crude extracts. (AU)

Articles published in other media outlets (1 total):
G1: Pesquisadores da UFU descobrem que oleorresina de árvores copaiferas pode impedir infecção causada pelo protozoário da toxoplasmose (06/Oct/2020)

Scientific publications (64)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SIMARO, GUILHERME VENANCIO; LEMOS, MARIVANE; DA SILVA, JONAS JOAQUIM MANGABEIRA; RIBEIRO, VICTOR PENA; ARRUDA, CAROLINE; SCHNEIDER, AYDA HENRIQUES; WANDERLEY, CARLOS WAGNER DE SOUZA; CARNEIRO, LUIZA JUNQUEIRA; MARIANO, ROBERTA LOPES; AMBROSIO, SERGIO RICARDO; DE ANDRADE, SERGIO FALONI; BANDERO-FILHO, VILMAR C.; SASSE, ASTRID; SHERIDAN, HELEN; ANDRADE E SILVA, MARCIO LUIS; BASTOS, JAIRO KENUPP. Antinociceptive and anti-inflammatory activities of Copaifera pubiflora Benth oleoresin and its major metabolite ent-hardwickiic acid. Journal of Ethnopharmacology, v. 271, MAY 10 2021. Web of Science Citations: 0.
FERREIRA, ALEXSANDRO EURIPEDES; FERREIRA SOARES ROCHA, ANA CAROLINA; BASTOS, JAIRO KENUPP; GOMES HELENO, VLADIMIR CONSTANTINO. Software-assisted methodology for complete assignment of H-1 and C-13 NMR data of poorly functionalized molecules: The case of the chemical marker diterpene ent-copalic acid. Journal of Molecular Structure, v. 1228, MAR 15 2021. Web of Science Citations: 0.
ABRAO, FARIZA; SILVA, THAYNA SOUZA; MOURA, CLAUDIA L.; AMBROSIO, SERGIO RICARDO; SOLA VENEZIANI, RODRIGO CASSIO; DE PAIVA, RAPHAEL E. F.; BASTOS, JAIRO KENUPP; GOMES MARTINS, CARLOS HENRIQUE. Oleoresins and naturally occurring compounds of Copaifera genus as antibacterial and antivirulence agents against periodontal pathogens. SCIENTIFIC REPORTS, v. 11, n. 1 MAR 2 2021. Web of Science Citations: 0.
GONCALVES DIAS, FERNANDA GOSUEN; PEREIRA, LUCAS DE FREITAS; FURTADO, RICARDO ANDRADE; MAGALHAES, GEORGIA MODE; MIGUEL, MARINA PACHECO; GOSUEN GONCALVES DIAS, LUIS GUSTAVO; JORGE, ADRIANA TORRECILHAS; HONSHO, CRISTIANE DOS SANTOS; AMBROSIO, SERGIO RICARDO; BASTOS, JAIRO KENUPP; CARRIJO, MICAELA SILVA; TAVARES, DENISE CRISPIM. Topical formulations containing Copaifera duckei Dwyer oleoresin improve cutaneous wound healing. AVICENNA JOURNAL OF PHYTOMEDICINE, v. 11, n. 2, p. 120-133, MAR-APR 2021. Web of Science Citations: 0.
DE OLIVEIRA, MARTA H.; GUSHIKEN, LUCAS F. S.; PELLIZZON, CLAUDIA H.; MANCERA, PAULO F. A. Mathematical modelling, parameter estimation and computational simulation for skin wound healing under Copaiferalangsdorffi treatments. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, v. 199, FEB 2021. Web of Science Citations: 0.
OLIVEIRA, LARISSA COSTA; PORTO, THIAGO SOUZA; COLMANETTE JUNIOR, ARTHUR HENRIQUE; CONCEICAO SANTOS, MARIO FERREIRA; RAMOS, HENRIQUE PEREIRA; BRAUN, GLAUCIA HOLLAENDER; DE LIMA PAULA, LUCAS ANTONIO; BASTOS, JAIRO KENUPP; JACOMETTI CARDOSO FURTADO, NIEGE ARACARI; TAME PARREIRA, RENATO LUIS; SOLA VENEZIANI, RODRIGO CASSIO; MAGALHAES, LIZANDRA GUIDI; AMBROSIO, SERGIO RICARDO. Schistosomicidal activity of kaurane, labdane and clerodane-type diterpenes obtained by fungal transformation. Process Biochemistry, v. 98, p. 34-40, NOV 2020. Web of Science Citations: 1.
SIMARO, GUILHERME VENANCIO; LEMOS, MARIVANE; DA SILVA, JONAS JOAQUIM MANGABEIRA; CUNHA, WILSON ROBERTO; CARNEIRO, LUIZA JUNQUEIRA; AMBROSIO, SERGIO RICARDO; CUNHA, NAYANNE LARISSA; DE ANDRADE, SERGIO FALONI; ARRUDA, CAROLINE; BANDERO-FILHO, VILMAR C.; SASSE, ASTRID; SHERIDAN, HELEN; BASTOS, JAIRO KENUPP; ANDRADE E SILVA, MARCIO LUIS. In vivo study of anti-inflammatory and antinociceptive activities of Copaifera pubiflora Benth oleoresin. NATURAL PRODUCT RESEARCH, NOV 2020. Web of Science Citations: 0.
ANDRADE, GESSICA; ORLANDO, HANIEL CHADWICK SILVA; SCORZONI, LILIANA; PEDROSO, REGINALDO SANTOS; ABRAO, FARIZA; CARVALHO, MARCO TULIO MENEZES; VENEZIANI, RODRIGO CASSIO SOLA; AMBROSIO, SERGIO RICARDO; BASTOS, JAIRO KENUPP; MENDES-GIANNINI, MARIA JOSE SOARES; MARTINS, CARLOS HENRIQUE GOMES; PIRES, REGINA HELENA. BrazilianCopaiferaSpecies: Antifungal Activity against Clinically RelevantCandidaSpecies, Cellular Target, and In Vivo Toxicity. JOURNAL OF FUNGI, v. 6, n. 3 SEP 2020. Web of Science Citations: 0.
MORAES, THAIS DA SILVA; LEANDRO, LUIS FERNANDO; SANTIAGO, MARIANA BRENTINI; SILVA, LARISSA DE OLIVEIRA; BIANCHI, THAMIRES CHIQUINI; VENEZIANI, RODRIGO CASSIO SOLA; AMBROSIO, SERGIO RICARDO; RAMOS, SALVADOR BOCCALETTI; BASTOS, JAIRO KENUPP; MARTINS, CARLOS HENRIQUE GOMES. Assessment of the antibacterial, antivirulence, and action mechanism of Copaifera pubiflora oleoresin and isolated compounds against oral bacteria. BIOMEDICINE & PHARMACOTHERAPY, v. 129, SEP 2020. Web of Science Citations: 0.
ALVES, JESSICA APARECIDA; ABRAO, FARIZA; MORAES, THAIS DA SILVA; DAMASCENO, JAQUELINE LOPES; DOS SANTOS MORAES, MARCOS FERNANDO; SOLA VENEZIANI, RODRIGO CASSIO; AMBROSIO, SERGIO RICARDO; BASTOS, JAIRO KENUPP; DANTAS MIRANDA, MAYKER LAZARO; GOMES MARTINS, CARLOS HENRIQUE. Investigation of Copaifera genus as a new source of antimycobaterial agents. FUTURE SCIENCE OA, v. 6, n. 7 AUG 2020. Web of Science Citations: 0.
CARNEIRO, LUIZA J.; TASSO, THERCIUS O.; SANTOS, MARIO F. C.; GOULART, MIRIAN O.; DOS SANTOS, RAQUEL; BASTOS, JAIRO K.; DA SILVA, JONAS J. M.; CROTTI, ANTONIO E. M.; PARREIRA, RENATO L. T.; ORENHA, RENATO P.; VENEZIANI, RODRIGO C. S.; AMBROSIO, SERGIO R. Copaifera multijuga, Copaifera pubiflora and Copaifera trapezifolia Oleoresins: Chemical Characterization and in vitro Cytotoxic Potential against Tumoral Cell Lines. Journal of the Brazilian Chemical Society, v. 31, n. 8, p. 1679-1689, AUG 2020. Web of Science Citations: 1.
DE SEIXAS, ARTHUR TAVARES; GALLANI, SILVIA UMEDA; NORONHA, LEILANE DA SILVA; MANGABEIRA SILVA, JONAS JOAQUIM; RIZZATO PASCHOAL, JONAS AUGUSTO; BASTOS, JAIRO KENUPP; RAMOS VALLADAO, GUSTAVO MORAES. Copaiferaoleoresins as a novel natural product against acanthocephalan in aquaculture: Insights in the mode of action and toxicity. AQUACULTURE RESEARCH, v. 51, n. 11 AUG 2020. Web of Science Citations: 0.
CECHINEL-ZANCHETT, CAMILE CECCONI; BOLDA MARIANO, LUISA NATHAPRIMELIA; BOEING, THAISE; DA COSTA, JULIANA DE CARVALHO; DA SILVA, LUISA MOTA; BASTOS, JAIRO K.; CECHINEL-FILHO, VALDIR; DE SOUZA, PRISCILA. Diuretic and Renal Protective Effect of Kaempferol 3-O-Alpha-L-rhamnoside (Afzelin) in Normotensive and Hypertensive Rats. Journal of Natural Products, v. 83, n. 6, p. 1980-1989, JUN 26 2020. Web of Science Citations: 0.
FERREIRA MENDES, FILIPE SANTOS; GARCIA, LETICIA MATANOVICH; MORAES, THAIS DA SILVA; CASEMIRO, LUCIANA ASSIRATI; DE ALCANTARA, CLAUBER BARBOSA; AMBROSIO, SERGIO RICARDO; SOLA VENEZIANI, RODRIGO CASSIO; DANTAS MIRANDA, MAYKER LAZARO; GOMES MARTINS, CARLOS HENRIQUE. Antibacterial activity of salvia officinalis L. against periodontopathogens: An in vitro study. Anaerobe, v. 63, JUN 2020. Web of Science Citations: 0.
CRUZ DE CARVALHO, TATIANE; DE OLIVEIRA SILVA, ELIANE; SOARES, GILBERTO AUGUSTO; PARREIRA, RENATO LUIS TAME; AMBROSIO, SERGIO RICARDO; JACOMETTI CARDOSO FURTADO, NIEGE ARACARI. Fungal biocatalysts for labdane diterpene hydroxylation. Bioprocess and Biosystems Engineering, v. 43, n. 6 FEB 2020. Web of Science Citations: 0.
DE SOUSA, INGRID PONTES; FERREIRA, ANTONIO GILBERTO; MILLER CROTTI, ANTONIO EDUARDO; DOS SANTOS, RAQUEL ALVES; KIERMAIER, JOSEF; KRAUS, BIRGIT; HEILMANN, JOERG; JACOMETTI CARDOSO FURTADO, NIEGE ARACARI. New antifungal ent-labdane diterpenes against Candida glabrata produced by microbial transformation of ent-polyalthic acid. BIOORGANIC CHEMISTRY, v. 95, JAN 2020. Web of Science Citations: 0.
MANGABEIRA DA SILVA, JONAS JOAQUIM; RIBEIRO, VICTOR PENA; LEMOS, MARIVANE; MILLER CROTTI, ANTONIO EDUARDO; ROGEZ, HERVE; BASTOS, JAIRO KENUPP. Reliable Methods for Analyses of Volatile Compounds of Copaifera Oleoresins Combining Headspace and Gas Chromatography. CHEMISTRY & BIODIVERSITY, v. 17, n. 1 DEC 2019. Web of Science Citations: 0.
CURCINO VIEIRA, MILENA G.; BRAZ FILHO, RAIMUNDO; CURCINO VIEIRA, IVO. J. Curcinomarcoide, a Novel Limonoid From Trichilia hirta (Meliaceae)Complete H-1 and C-13 Chemical Shift Assignments. NATURAL PRODUCT COMMUNICATIONS, v. 14, n. 5 MAY 2019. Web of Science Citations: 0.
MOTTA, ERICK V. S.; SAMPAIO, BRUNO L.; COSTA, JULIANA C.; TEIXEIRA, SIMONE P.; BASTOS, JAIRO K. Quantitative analysis of phenolic metabolites in Copaifera langsdorffii leaves from plants of different geographic origins cultivated under the same environmental conditions. Phytochemical Analysis, v. 30, n. 3, p. 364-372, MAY-JUN 2019. Web of Science Citations: 0.
CHIBAS, LENIHER CASTAN; CINTRA, PRISCILA PAVINI; MOREIRA, MONIQUE RODRIGUES; GOULART, MIRIAN OLIVEIRA; AMBROSIO, SERGIO RICARDO; SOLA VENEZIANI, RODRIGO CASSIO; BASTOS, JAIRO KENUPP; DOS SANTOS, RAQUEL ALVES. Polyalthic Acid in Polymeric Nanoparticles Causes Selective Growth Inhibition and Genotoxicity in MCF-7 Cells. NATURAL PRODUCT COMMUNICATIONS, v. 14, n. 4 APR 2019. Web of Science Citations: 0.
SENEDESE, JULIANA MARQUES; RINALDI-NETO, FRANCISCO; FURTADO, RICARDO ANDRADE; NICOLLELA, HELOIZA DINIZ; RIBEIRO DE SOUZA, LARISSA DANIELA; RIBEIRO, ARTHUR BARCELOS; FERREIRA, LUCAS SOUZA; MAGALHAES, GEORGIA MODE; CARLOS, IRACILDA ZEPPONE; MANGABEIRA DA SILVA, JONAS JOAQUIM; TAVARES, DENISE CRISPIM; BASTOS, JAIRO KENUPP. Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis. BIOMEDICINE & PHARMACOTHERAPY, v. 111, p. 331-337, MAR 2019. Web of Science Citations: 0.
DA COSTA, JULIANA DE CARVALHO; MOTTA, ERICK V. S.; BARRETO, FABIANO; DE ARAUJO, BIBIANA VERLINDO; DERENDORF, HARTMUT; BASTOS, JAIRO KENUPP. Development and Validation of a Sensitive UFLC-MS/MS Method for Quantification of Quercitrin in Plasma: Application to a Tissue Distribution Study. ACS OMEGA, v. 4, n. 2, p. 3527-3533, FEB 2019. Web of Science Citations: 0.
RIBEIRO, VICTOR PENA; ARRUDA, CAROLINE; MANGABEIRA DA SILVA, JONAS JOAQUIM; ALDANA MEJIA, JENNYFER ANDREA; JACOMETTI CARDOSO FURTADO, NIEGE ARACARI; BASTOS, JAIRO KENUPP. Use of spinning band distillation equipment for fractionation of volatile compounds of Copaifera oleoresins for developing a validated gas chromatographic method and evaluating antimicrobial activity. BIOMEDICAL CHROMATOGRAPHY, v. 33, n. 2 FEB 2019. Web of Science Citations: 1.
ARRUDA, CAROLINE; ALDANA MEJIA, JENNYFER ANDREA; RIBEIRO, VICTOR PENA; GAMBETA BORGES, CARLY HENRIQUE; GOMES MARTINS, CARLOS HENRIQUE; SOLA VENEZIANI, RODRIGO CASSIO; AMBROSIO, SERGIO RICARDO; BASTOS, JAIRO KENUPP. Occurrence, chemical composition, biological activities and analytical methods on Copaifera genus-A review. BIOMEDICINE & PHARMACOTHERAPY, v. 109, p. 1-20, JAN 2019. Web of Science Citations: 4.
DAMASCENO, JAQUELINE LOPES; ARNET, YADIRA FERNANDEZ; FORTUNATO, GIOVANNA CAPALDI; GIROTTO, LUIZA; MARENA, GABRIEL DAVI; ROCHA, BEATRIZ PATTI; RESENDE, FLAVIA APARECIDA; AMBROSIO, SERGIO RICARDO; SOLA VENEZIANI, RODRIGO CASSIO; BASTOS, JAIRO KENUPP; GOMES MARTINS, CARLOS HENRIQUE. Investigation of Safety Profile of Four Copaifera Species and of Kaurenoic Acid by Salmonella/Microsome Test. Evidence-based Complementary and Alternative Medicine, 2019. Web of Science Citations: 1.
DA COSTA, RICARDO M.; BASTOS, JAIRO K.; COSTA, MARIA C. A.; FERREIRA, MARCIA M. C.; MIZUNO, CASSIA S.; CARAMORI, GIOVANNI F.; NAGURNIAK, GLAUCIO R.; SIMAO, MARILIA R.; DOS SANTOS, RAQUEL A.; VENEZIANI, RODRIGO C. S.; AMBROSIO, SERGIO R.; PARREIRA, RENATO L. T. In vitro cytotoxicity and structure-activity relationship approaches of ent-kaurenoic acid derivatives against human breast carcinoma cell line. Phytochemistry, v. 156, p. 214-223, DEC 2018. Web of Science Citations: 1.
AGUIAR, GABRIELA P.; CREVELIN, EDUARDO J.; DIAS, HERBERT J.; AMBROSIO, SERGIO R.; BASTOS, JAIRO K.; HELENO, VLADIMIR C. G.; VESSECCHI, RICARDO; CROTTI, ANTONIO E. M. Electrospray ionization tandem mass spectrometry of labdane-type acid diterpenes. Journal of Mass Spectrometry, v. 53, n. 11, p. 1086-1096, NOV 2018. Web of Science Citations: 1.
FERNANDEZ, YADIRA ARNET; DAMASCENO, JAQUELINE LOPES; ABRAO, FARIZA; SILVA, THAYNA DE SOUZA; PIZI CANDIDO, AMANDA DE LIMA; FREGONEZI, NATHALIA FERREIRA; RESENDE, FLAVIA APARECIDA; RAMOS, SALVADOR BOCCALETTI; AMBROSIO, SERGIO RICARDO; SOLA VENEZIANI, RODRIGO CASSIO; BASTOS, JAIRO KNUPP; GOMES MARTINS, CARLOS HENRIQUE. Antibacterial, Preservative, and Mutagenic Potential of Copaifera spp. Oleoresins Against Causative Agents of Foodborne Diseases. FOODBORNE PATHOGENS AND DISEASE, v. 15, n. 12 SEP 19 2018. Web of Science Citations: 1.
MENDES DE SOUZA, MARIA GORETE; LEANDRO, LUIS FERNANDO; MORAES, THAIS DA SILVA; ABRAO, FARIZA; SOLA VENEZIANI, RODRIGO CASSIO; AMBROSIO, SERGIO RICARDO; GOMES MARTINS, CARLOS HENRIQUE. ent-Copalic acid antibacterial and anti-biofilm properties against Actinomyces naeslundii and Peptostreptococcus anaerobius. Anaerobe, v. 52, p. 43-49, AUG 2018. Web of Science Citations: 2.
FURTADO, RICARDO ANDRADE; DE OLIVEIRA, POLLYANNA FRANCIELLI; SENEDESE, JULIANA MARQUES; OZELIN, SAULO DUARTE; RIBEIRO DE SOUZ, LARISSA DANIELA; LEANDRO, LUIS FERNANDO; DE OLIVEIRA, WENDEL LUIZ; MANGABEIRA DA SILVA, JONAS JOAQUIM; OLIVEIRA, LARISSA COSTA; ROGEZ, HERVE; AMBROSIO, SERGIO RICARDO; SOLA VENEZIANI, RODRIGO CASSIO; BASTOS, JAIRO KENUPP; TAVARES, DENISE CRISPIM. Assessment of genotoxic activity of oleoresins and leaves extracts of six Copaifera species for prediction of potential human risks. Journal of Ethnopharmacology, v. 221, p. 119-125, JUL 15 2018. Web of Science Citations: 5.
CARNEIRO, LUIZA J.; BIANCHI, THAMIRES C.; DA SILVA, JONAS J. M.; OLIVEIRA, LARISSA C.; BORGES, CARLY H. G.; LEMES, DANIELI C.; BASTOS, JAIRO K.; VENEZIANI, RODRIGO C. S.; AMBROSIO, SERGIO R. Development and Validation of a Rapid and Reliable RP-HPLC-PDA Method for the Quantification of Six Diterpenes in Copaifera duckei, Copaifera reticulata and Copaifera multijuga Oleoresins. Journal of the Brazilian Chemical Society, v. 29, n. 4, p. 729-737, APR 2018. Web of Science Citations: 2.
EL-SALAM, MOHAMED ABD; BASTOS, JAIRO KENUPP; HAN, JING JING; PREVIDI, DANIEL; COELHO, EDUARDO B.; DONATE, PAULO M.; ROMERO, MICHAEL F.; LIESKE, JOHN. The Syntheized Plant Metabolite 3,4,5-Tri-O-Galloylquinic Acid Methyl Ester Inhibits Calcium Oxalate Crystal Growth in a Drosophila Model, Downregulates Renal Cell Surface Annexin A1 Expression, and Decreases Crystal Adhesion to Cells. Journal of Medicinal Chemistry, v. 61, n. 4, p. 1609-1621, FEB 22 2018. Web of Science Citations: 2.
ABRAO, FARIZA; ALVES, JESSICA A.; ANDRADE, GESSICA; DE OLIVEIRA, POLLYANNA F.; AMBROSIO, SERGIO R.; VENEZIANI, RODRIGO C. S.; TAVARES, DENISE C.; BASTOS, JAIRO K.; MARTINS, CARLOS H. G. Antibacterial Effect of Copaifera duckei Dwyer Oleoresin and Its Main Diterpenes against Oral Pathogens and Their Cytotoxic Effect. FRONTIERS IN MICROBIOLOGY, v. 9, FEB 21 2018. Web of Science Citations: 1.
LEITE VIEIRA, ROSIMARA GONCALVES; MORAES, THAIS DA SILVA; SILVA, LARISSA DE OLIVEIRA; BIANCHI, THAMIRES CHIQUINI; SOLA VENEZIANI, RODRIGO CASSIO; AMBROSIO, SERGIO RICARDO; BASTOS, JAIRO KENUPP; PIRES, REGINA HELENA; GOMES MARTINS, CARLOS HENRIQUE. In vitro studies of the antibacterial activity of Copaifera spp. oleoresins, sodium hypochlorite, and peracetic acid against clinical and environmental isolates recovered from a hemodialysis unit. ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL, v. 7, JAN 24 2018. Web of Science Citations: 3.
ALVES, JACQUELINE MORAIS; LEANDRO, LUIS FERNANDO; SENEDESE, JULIANA MARQUES; DE CASTRO, PAMELA TINTI; PEREIRA, DAIANE ELEUTERIO; RESENDE, FLAVIA APARECIDA; CAMPOS, DEBORA LEITE; MANGABEIRA DA SILVA, JONAS JOAQUIM; VARANDA, ELIANA APARECIDA; BASTOS, JAIRO KENUPP; AMBROSIO, SERGIO RICARDO; TAVARES, DENISE CRISPIM. Antigenotoxicity properties of Copaifera multijuga oleoresin and its chemical marker, the diterpene (-)-copalic acid. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, v. 81, n. 5, p. 116-129, 2018. Web of Science Citations: 5.
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