Chemical and pharmacological validation of extracts and active compounds of Copaifera species

• Grant number: 11/13630-7
• Support Opportunities: Research Projects - Thematic Grants
• Duration: April 01, 2012 - March 31, 2017
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Jairo Kenupp Bastos
• Grantee: Jairo Kenupp Bastos
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Pesquisadores principais: Lizandra Guidi Magalhães
• Associated researchers: Antônio Eduardo Miller Crotti ; Carlos Henrique Gomes Martins ; Claudia Helena Pellizzon ; Denise Crispim Tavares Barbosa ; Hervé Louis Ghislain Rogez ; José Maurício Sforcin ; Luis Alexandre Pedro de Freitas ; Luiz Alberto Beraldo de Moraes ; Márcio Luís Andrade e Silva ; Niege Araçari Jacometti Cardoso Furtado ; Raquel Alves dos Santos ; Rodrigo Cassio Sola Veneziani ; Sergio Akira Uyemura ; Sergio Ricardo Ambrosio ; Vanderlei Rodrigues ; Vera Lúcia Lanchote ; Vladimir Constantino Gomes Heleno ; Wilson Roberto Cunha
• Associated grant(s): 14/04464-4 - 55th Annual Meeting of the American Society of Pharmacognosy & 14th Annual Oxford International Conference on the Science of Botanicals, AR.EXT
• Associated scholarship(s): 17/02592-3 - Biotransformation of cubebin and hardwickiic acid by Cunninghamella echinulata and biological activities evaluation, BP.MS; 16/20589-7 - Copaifera lucens: antibacterial action of the hydroalcoholic crude extract and the oleoresin against oral pathogens and its cytotoxic and genotoxic potential, BP.IC; 15/23154-9 - Histological analysis of the cicatrization in chemical ulcers after treatment the copaiba oil (Copaifera Hayne multijuga), with concentration of the 3%, BP.IC; + associated scholarships 15/17641-4 - Histological evaluation of the effect of copaiba oil (Copaifera multijuga Hayne) at a concentration of 1% on the healing of corneal ulcers caused by chemical burns in rats, BP.IC; 16/07075-4 - In vitro susceptibility of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans against oleoresin and compounds isolated from species of Copaifera spp, BP.IC; 16/01232-0 - Copaifera oleoresins: development and validation of a HPLC-DAD analytical method and phytochemical study and in vitro antitumor evaluation of the main secondary metabolites obtained, BP.DD; 15/12372-5 - Cytotoxic and genotoxic potential study of Copaifera lucens in extract cells of mammals in vitro and in vivo, BP.IC; 15/19714-9 - A preliminary investigation of the anti-Helicobacter pylori by some Copaifera spp. species, BP.IC; 14/23684-5 - Evaluation of cellular and molecular mechanisms in skin wound healing using Copaifera langsdorffii hydroalcoholic extract and oil resin ointments, BP.MS; 15/05954-8 - Potential antigenotoxic and against poisoning by methylmercury and lead of flavonoids and galloylquinic compounds from Copaifera langsdorffii Desf., BP.MS; 14/13094-6 - Evaluation of cell death induction by Copaifera duckei oleoresin and polyaltic acid in MCF-7 cell line, BP.IC; 14/09528-0 - Bioactivity analysis of crude hydroalcoholic extract of leaves and oleoresin of Copaifera multijuga against oral pathogens, BP.IC; 14/03092-6 - Chemical validation and in vitro antitumor activity of secondary metabolites obtained from the oleoresin of Copaifera multijuga, BP.MS; 13/19488-3 - In vivo and in vitro evaluation of chemo preventive potential of Copaifera reticulata Ducke oil-resin: genotoxic, biochemical and immunohistochemical parameters, BP.PD; 13/21167-0 - Antiparasitary potential evaluation for a group of labdane diterpenes against Leishmania amazonensis, BP.IC; 12/24856-9 - Copaifera duckei Dwyer: EVALUATION OF ANTIBACTERIAL POTENTIAL AGAINST BUCCAL PATHOGENS AND CYTOTOXICITY, BP.MS; 13/06591-0 - Chemical study of the hydroalcoholic extract of the leaves of Copaifera oblongifolia and antiparasitic assays, BP.IC; 12/24200-6 - In vitro antitumor activity of secondary metabolites obtained from the oleoresin of Copaifera duckei, BP.IC; 12/22832-5 - Fragmentation studies on labdane-type diterpenes isolated from Copaifera langsdorffii oleoresin using tandem mass spectrometry, BP.MS; 12/15092-5 - This project is integrant of chemical and pharmacological validation of extracts and active compounds of copaifera speci, BP.IC; 12/12881-9 - Antibacterial activity of the crude extract and derivatives from Copaifera langsdorffii against planktonic and sessile anaerobic bacteria, BP.IC; 12/02082-1 - Copaifera langsdorffii: development of liposomes stabilized by spray freeze drying with selective antitumor action, BP.DR; 12/08335-9 - Study of antibacterial, mutagenic and cytotoxic potential of crude hydroalcoholic extract from Copaifera trapezifolia, BP.MS - associated scholarships

Abstract

Despite the wide folk use of copaiba oil resin by the Brazilians since XIX century, the several studies corroborating many of its ethnopharmacological uses, and its production being around 800 tons per year, there is a great need of undertaking phytochemical, pharmacological, toxicological and clinical studies, aiming to guarantee the safety, efficacy and quality, which are mandatory for developing new phytomedicines. It should be pointed out that the majority of the reported data are related to the crude oil resin and there are few studies on the aerial parts of Copaifera plants. Therefore, the goal of this proposal is to undertake a wide study with eight species of Copaifera, such as: C. duckei Dwyer, C. martii Hayne, C. reticulata Ducke, C. multijuga Hayne e C. piresii Ducke, C. langsdorffii Desff, C. trapezifolia Hayne e C. officinalis (Jacq.) L, aiming to undertake the chemical and pharmacological validation, as well as the standardization of these plants extracts to establish the bases for the development of new medicines. For that, a multidisciplinary team will undertake the following: metabolomic study of the oil resins and the leaf extracts for the isolation and identification of the major secondary metabolites, to be used as chromatographic standards and in the biological assays; development of analytical methods and desreplication studies to guide both the phytochemical and seasonal studies; investigation of the anti-inflammatory, analgesic, immunomodulatory, wound healing, antimicrobial, antiparasitical and antitumor activities for the crude extracts and major isolated compounds; determination of both in vitro and in vivo toxicological parameters; studies of biotransformation by the gut bacteria; pharmacokinetic studies of the selected extracts and isolated compounds, as well as the use of spray drier technique to produce standardized crude extracts. (AU)

Scientific publications

(87)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SIMARO, GUILHERME VENANCIO; LEMOS, MARIVANE; DA SILVA, JONAS JOAQUIM MANGABEIRA; CUNHA, WILSON ROBERTO; CARNEIRO, LUIZA JUNQUEIRA; AMBROSIO, SERGIO RICARDO; CUNHA, NAYANNE LARISSA; DE ANDRADE, SERGIO FALONI; ARRUDA, CAROLINE; BANDERO-FILHO, VILMAR C.; et al. In vivo study of anti-inflammatory and antinociceptive activities of Copaifera pubiflora Benth oleoresin. NATURAL PRODUCT RESEARCH, NOV 2020. (11/13630-7)

FONSECA, ARIANA P.; ESTRELA, FERNANDA T.; MORAES, THAIS S.; CARNEIRO, LUIZA J.; BASTOS, JAIRO K.; DOS SANTOS, RAQUEL A.; AMBROSIO, SERGIO R.; MARTINS, CARLOS H. G.; VENEZIANI, RODRIGO C. S.. In Vitro Antimicrobial Activity of Plant-Derived Diterpenes against Bovine Mastitis Bacteria. Molecules, v. 18, n. 7, p. 7865-7872, JUL 2013. (11/13630-7)

DA COSTA, RICARDO M.; BASTOS, JAIRO K.; COSTA, MARIA C. A.; FERREIRA, MARCIA M. C.; MIZUNO, CASSIA S.; CARAMORI, GIOVANNI F.; NAGURNIAK, GLAUCIO R.; SIMAO, MARILIA R.; DOS SANTOS, RAQUEL A.; VENEZIANI, RODRIGO C. S.; et al. In vitro cytotoxicity and structure-activity relationship approaches of ent-kaurenoic acid derivatives against human breast carcinoma cell line. Phytochemistry, v. 156, p. 214-223, DEC 2018. (11/13630-7, 11/23028-2, 07/54762-8, 11/07623-8)

ALVES, JACQUELINE M.; SENEDESE, JULIANA M.; LEANDRO, LUIS F.; CASTRO, PAMELA T.; PEREIRA, DAIANE E.; CARNEIRO, LUIZA J.; AMBROSIO, SERGIO R.; BASTOS, JAIRO K.; TAVARES, DENISE C.. Copaifera multijuga oleoresin and its constituent diterpene (-)-copalic acid: Genotoxicity and chemoprevention study. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, v. 819, p. 26-30, JUL 2017. (11/13630-7, 09/17237-8)

NOGUEIRA, MAURO S.; FURTADO, RICARDO A.; BASTOS, JAIRO K.. Flavonoids and Methoxy-galloyiquinic Acid Derivatives from the Leaf Extract of Copaifera langsdorffii Desf.. Journal of Agricultural and Food Chemistry, v. 63, n. 31, p. 6939-6945, AUG 12 2015. (09/10975-3, 11/13630-7)

LEMOS, MARIVANE; SANTIN, JOSE ROBERTO; MIZUNO, CASSIA SUEMI; BOEING, THAISE; BARRETO DE SOUSA, JOAO PAULO; NANAYAKKARA, DHAMMIKA; BASTOS, JAIRO KENUPP; DE ANDRADE, SERGIO FALONI. Copaifera langsdorffii: evaluation of potential gastroprotective of extract and isolated compounds obtained from leaves. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 25, n. 3, p. 238-245, MAY-JUN 2015. (11/13630-7)

MOREIRA, MONIQUE RODRIGUES; SOUZA, ARIANA BORGES; SOARES, SANDRA; BIANCHI, THAMIRES CHIQUINI; EUGENIO, DANIELE DE SOUZA; LEMES, DANIELI CRISTINA; GOMES MARTINS, CARLOS HENRIQUE; MORAES, THAIS DA SILVA; TAVARES, DENISE CRISPIM; FERREIRA, NATALIA HELEN; et al. ent-Kaurenoic acid-rich extract from Mikania glomerata: In vitro activity against bacteria responsible for dental caries. Fitoterapia, v. 112, p. 211-216, JUL 2016. (09/17700-0, 11/13630-7)

SIMPLICIO, JANAINA A.; SIMAO, MARILIA R.; AMBROSIO, SERGIO R.; TIRAPELLI, CARLOS R.. O Labdano Ácido Ent-3-Acetóxi-Labda-8(17),13-Dieno-15-Óico Reduz Pressão Arterial Em Ratos Hipertensos. Arquivos Brasileiros de Cardiologia, v. 106, n. 6, p. 481-490, JUN 2016. (10/01009-3, 11/13630-7)

ANDRADE, GESSICA; ORLANDO, HANIEL CHADWICK SILVA; SCORZONI, LILIANA; PEDROSO, REGINALDO SANTOS; ABRAO, FARIZA; CARVALHO, MARCO TULIO MENEZES; VENEZIANI, RODRIGO CASSIO SOLA; AMBROSIO, SERGIO RICARDO; BASTOS, JAIRO KENUPP; MENDES-GIANNINI, MARIA JOSE SOARES; et al. BrazilianCopaiferaSpecies: Antifungal Activity against Clinically RelevantCandidaSpecies, Cellular Target, and In Vivo Toxicity. JOURNAL OF FUNGI, v. 6, n. 3, SEP 2020. (17/03250-9, 18/02333-0, 11/13630-7)

FERNANDEZ, YADIRA ARNET; DAMASCENO, JAQUELINE LOPES; ABRAO, FARIZA; SILVA, THAYNA DE SOUZA; PIZI CANDIDO, AMANDA DE LIMA; FREGONEZI, NATHALIA FERREIRA; RESENDE, FLAVIA APARECIDA; RAMOS, SALVADOR BOCCALETTI; AMBROSIO, SERGIO RICARDO; SOLA VENEZIANI, RODRIGO CASSIO; et al. Antibacterial, Preservative, and Mutagenic Potential of Copaifera spp. Oleoresins Against Causative Agents of Foodborne Diseases. FOODBORNE PATHOGENS AND DISEASE, v. 15, n. 12, SEP 19 2018. (11/13630-7)

MENDES DE SOUZA, MARIA GORETE; LEANDRO, LUIS FERNANDO; MORAES, THAIS DA SILVA; ABRAO, FARIZA; SOLA VENEZIANI, RODRIGO CASSIO; AMBROSIO, SERGIO RICARDO; GOMES MARTINS, CARLOS HENRIQUE. ent-Copalic acid antibacterial and anti-biofilm properties against Actinomyces naeslundii and Peptostreptococcus anaerobius. Anaerobe, v. 52, p. 43-49, AUG 2018. (11/13630-7, 12/25237-0)

FERREIRA MENDES, FILIPE SANTOS; GARCIA, LETICIA MATANOVICH; MORAES, THAIS DA SILVA; CASEMIRO, LUCIANA ASSIRATI; DE ALCANTARA, CLAUBER BARBOSA; AMBROSIO, SERGIO RICARDO; SOLA VENEZIANI, RODRIGO CASSIO; DANTAS MIRANDA, MAYKER LAZARO; GOMES MARTINS, CARLOS HENRIQUE. Antibacterial activity of salvia officinalis L. against periodontopathogens: An in vitro study. Anaerobe, v. 63, JUN 2020. (12/12880-2, 11/13630-7)

CARNEIRO, LUIZA J.; TASSO, THERCIUS O.; SANTOS, MARIO F. C.; GOULART, MIRIAN O.; DOS SANTOS, RAQUEL; BASTOS, JAIRO K.; DA SILVA, JONAS J. M.; CROTTI, ANTONIO E. M.; PARREIRA, RENATO L. T.; ORENHA, RENATO P.; et al. Copaifera multijuga, Copaifera pubiflora and Copaifera trapezifolia Oleoresins: Chemical Characterization and in vitro Cytotoxic Potential against Tumoral Cell Lines. Journal of the Brazilian Chemical Society, v. 31, n. 8, p. 1679-1689, AUG 2020. (16/01232-0, 11/13630-7)

GUSHIKEN, LUCAS FERNANDO SERGIO; BESERRA, FERNANDO PEREIRA; HUSSNI, MARIA FERNANDA; GONZAGA, MURILO TIRELI; RIBEIRO, VICTOR PENA; DE SOUZA, PATRICIA FERNANDA; CAMPOS, JACQUELINE COSTA LIMA; MASSARO, TAIS NADER CHRYSOSTOMO; HUSSNI, CARLOS ALBERTO; TAKAHIRA, REGINA KIOMI; et al. Beta-caryophyllene as an antioxidant, anti-inflammatory and re-epithelialization activities in a rat skin wound excision model. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, v. 2022, p. 21-pg., 2022-02-03. (17/04138-8, 11/13630-7, 17/17600-1)

CURCINO VIEIRA, MILENA G.; BRAZ FILHO, RAIMUNDO; CURCINO VIEIRA, IVO. J.. Curcinomarcoide, a Novel Limonoid From Trichilia hirta (Meliaceae)Complete H-1 and C-13 Chemical Shift Assignments. NATURAL PRODUCT COMMUNICATIONS, v. 14, n. 5, MAY 2019. (11/13630-7, 14/12465-0)

DA COSTA, JAQUELINE CUSTODIO; RAMOS VALLADAO, GUSTAVO MORAES; PALA, GABRIELA; GALLANI, SILVIA UMEDA; KOTZENT, SUZANA; MILLER CROTTI, ANTONIO EDUARDO; FRACAROLLI, LETICIA; MANGABEIRA DA SILVA, JONAS JOAQUIM; PILARSKI, FABIANA. Copaifera duckei oleoresin as a novel alternative for treatment of monogenean infections in pacu Piaractus mesopotamicus. Aquaculture, v. 471, p. 72-79, MAR 20 2017. (11/13630-7)

DA COSTA, JULIANA DE CARVALHO; MOTTA, ERICK V. S.; BARRETO, FABIANO; DE ARAUJO, BIBIANA VERLINDO; DERENDORF, HARTMUT; BASTOS, JAIRO KENUPP. Development and Validation of a Sensitive UFLC-MS/MS Method for Quantification of Quercitrin in Plasma: Application to a Tissue Distribution Study. ACS OMEGA, v. 4, n. 2, p. 3527-3533, FEB 2019. (13/09666-1, 11/13630-7, 12/03852-5)

AGUIAR, GABRIELA P.; CREVELIN, EDUARDO J.; DIAS, HERBERT J.; AMBROSIO, SERGIO R.; BASTOS, JAIRO K.; HELENO, VLADIMIR C. G.; VESSECCHI, RICARDO; CROTTI, ANTONIO E. M.. Electrospray ionization tandem mass spectrometry of labdane-type acid diterpenes. Journal of Mass Spectrometry, v. 53, n. 11, p. 1086-1096, NOV 2018. (13/20094-0, 11/13630-7, 12/22832-5, 14/23604-1)

MANGABEIRA DA SILVA, JONAS JOAQUIM; RIBEIRO, VICTOR PENA; LEMOS, MARIVANE; MILLER CROTTI, ANTONIO EDUARDO; ROGEZ, HERVE; BASTOS, JAIRO KENUPP. Reliable Methods for Analyses of Volatile Compounds of Copaifera Oleoresins Combining Headspace and Gas Chromatography. CHEMISTRY & BIODIVERSITY, v. 17, n. 1, DEC 2019. (11/13630-7)

DE SOUSA, INGRID PONTES; FERREIRA, ANTONIO GILBERTO; MILLER CROTTI, ANTONIO EDUARDO; DOS SANTOS, RAQUEL ALVES; KIERMAIER, JOSEF; KRAUS, BIRGIT; HEILMANN, JOERG; JACOMETTI CARDOSO FURTADO, NIEGE ARACARI. New antifungal ent-labdane diterpenes against Candida glabrata produced by microbial transformation of ent-polyalthic acid. BIOORGANIC CHEMISTRY, v. 95, JAN 2020. (11/13630-7, 16/25201-7)

MORAES, THAIS DA S.; LEANDRO, LUIS F.; SILVA, LARISSA DE O.; SANTIAGO, MARIANA B.; SOUZA, ARIANA B.; FURTADO, RICARDO A.; TAVARES, DENISE C.; VENEZIANI, RODRIGO C. S.; AMBROSIO, SERGIO R.; BASTOS, JAIRO K.; et al. In vitro Evaluation of Copaifera oblongifolia Oleoresin Against Bacteria Causing Oral Infections and Assessment of Its Cytotoxic Potential. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, v. 17, n. 10, p. 894-904, 2016. (11/13630-7, 12/25237-0)

BORGES, CARLY H. G.; CRUZ, MICHELE G.; CARNEIRO, LUIZA J.; DA SILVA, JONAS J. M.; BASTOS, JAIRO K.; TAVARES, DENISE C.; DE OLIVEIRA, POLLYANNA F.; RODRIGUES, VANDERLEI; VENEZIANI, RODRIGO C. S.; PARREIRA, RENATO L. T.; et al. Copaifera duckei Oleoresin and Its Main Nonvolatile Terpenes: In Vitro Schistosomicidal Properties. CHEMISTRY & BIODIVERSITY, v. 13, n. 10, p. 1348-1356, OCT 2016. (13/10132-1, 11/13630-7)

SANTIAGO, KARINA BASSO; CONTI, BRUNO JOSE; MURBACH TELES ANDRADE, BRUNA FERNANDA; MANGABEIRA DA SILVA, JONAS JOAQUIM; GHISLAIN ROGEZ, HERVE LOUIS; CREVELIN, EDUARDO JOSE; BERALDO DE MORAES, LUIZ ALBERTO; VENEZIANI, RODRIGO; AMBROSIO, SERGIO RICARDO; BASTOS, JAIRO KENUPP; et al. Immunomodulatory action of Copaifera spp oleoresins on cytokine production by human monocytes. BIOMEDICINE & PHARMACOTHERAPY, v. 70, p. 12-18, MAR 2015. (11/13630-7)

SIMAO, MARILIA R.; CARNEIRO, LUIZA J.; DOS SANTOS, RAQUEL A.; BASTOS, JAIRO K.; VENEZIANI, RODRIGO C. S.; AMBROSIO, SERGIO R.; MIZUNO, CASSIA S.. In vitro cytotoxicity study of ent-kaurenoic acid derivatives against human breast carcinoma cell line. MEDICINAL CHEMISTRY RESEARCH, v. 25, n. 2, p. 303-309, FEB 2016. (11/23028-2, 11/13630-7)

ABRAO, FARIZA; DE ARAUJO COSTA, LUCIANA DELFINO; ALVES, JACQUELINE MORAIS; SENEDESE, JULIANA MARQUES; DE CASTRO, PAMELA TINTI; AMBROSIO, SERGIO RICARDO; SOLA VENEZIANI, RODRIGO CASSIO; BASTOS, JAIRO KENUPP; TAVARES, DENISE CRISPIM; MARTINS, CARLOS HENRIQUE G.. Copaifera langsdorffii oleoresin and its isolated compounds: antibacterial effect and antiproliferative activity in cancer cell lines. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, v. 15, DEC 21 2015. (11/13630-7, 11/09229-5, 09/17237-8)

EL-SALAM, MOHAMED ABD; BASTOS, JAIRO KENUPP; HAN, JING JING; PREVIDI, DANIEL; COELHO, EDUARDO B.; DONATE, PAULO M.; ROMERO, MICHAEL F.; LIESKE, JOHN. The Syntheized Plant Metabolite 3,4,5-Tri-O-Galloylquinic Acid Methyl Ester Inhibits Calcium Oxalate Crystal Growth in a Drosophila Model, Downregulates Renal Cell Surface Annexin A1 Expression, and Decreases Crystal Adhesion to Cells. Journal of Medicinal Chemistry, v. 61, n. 4, p. 1609-1621, FEB 22 2018. (11/13630-7)

ABRAO, FARIZA; ALVES, JESSICA A.; ANDRADE, GESSICA; DE OLIVEIRA, POLLYANNA F.; AMBROSIO, SERGIO R.; VENEZIANI, RODRIGO C. S.; TAVARES, DENISE C.; BASTOS, JAIRO K.; MARTINS, CARLOS H. G.. Antibacterial Effect of Copaifera duckei Dwyer Oleoresin and Its Main Diterpenes against Oral Pathogens and Their Cytotoxic Effect. FRONTIERS IN MICROBIOLOGY, v. 9, FEB 21 2018. (12/24856-9, 12/25237-0, 11/13630-7)

DA SILVA MOTTA, ERICK VICENTE; DA COSTA, JULIANA DE CARVALHO; BASTOS, JAIRO KENUPP. A validated HPLC-UV method for the analysis of galloylquinic acid derivatives and flavonoids in Copaifera langsdorffii leaves. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, v. 1061, p. 240-247, SEP 1 2017. (12/03852-5, 11/13630-7, 12/01336-0)

SOUZA, ARIANA BORGES; MOREIRA, MONIQUE RODRIGUES; GAMBETA BORGES, CARLY HENRIQUE; SIMAO, MARILIA RODRIGUES; BASTOS, JAIRO KENUPP; BARRETO DE SOUSA, JOAO PAULO; AMBROSIO, SERGIO RICARDO; SOLA VENEZIANI, RODRIGO CASSIO. Development and validation of a rapid RP-HPLC method for analysis of (-)-copalic acid in copaiba oleoresin. BIOMEDICAL CHROMATOGRAPHY, v. 27, n. 3, p. 280-283, MAR 2013. (11/13630-7, 09/12796-9)

MORAES, THAIS DA SILVA; LEANDRO, LUIS FERNANDO; SANTIAGO, MARIANA BRENTINI; SILVA, LARISSA DE OLIVEIRA; BIANCHI, THAMIRES CHIQUINI; VENEZIANI, RODRIGO CASSIO SOLA; AMBROSIO, SERGIO RICARDO; RAMOS, SALVADOR BOCCALETTI; BASTOS, JAIRO KENUPP; MARTINS, CARLOS HENRIQUE GOMES. Assessment of the antibacterial, antivirulence, and action mechanism of Copaifera pubiflora oleoresin and isolated compounds against oral bacteria. BIOMEDICINE & PHARMACOTHERAPY, v. 129, SEP 2020. (11/13630-7)

SOUSA TEIXEIRA, M., V; FERNANDES, L. M.; DE PAULA, V. STEFANELLI; FERREIRA, A. G.; JACOMETTI CARDOSO FURTADO, N. A.. Ent-hardwickiic acid from C. pubiflora and its microbial metabolites are more potent than fluconazole in vitro against Candida glabrata. Letters in Applied Microbiology, v. 74, n. 4, p. 8-pg., 2022-01-17. (11/13630-7, 16/25201-7, 17/20397-3, 17/20071-0)

ARGENTIN, MARCELA NUNES; CRUZ, FELIPE DE PAULA NOGUEIRA; SOUZA, ARIANA BORGES; D'AUREA, ELISA MARCELA DE OLIVEIRA; BASTOS, JAIRO KENUPP; AMBROSIO, SERGIO RICARDO; VENEZIANI, RODRIGO CASSIO SOLA; CAMARGO, ILANA LOPES BARATELLA CUNHA; MIZUNO, CASSIA SUEMI. Synthesis and Antibacterial Activity of Polyalthic Acid Analogs. ANTIBIOTICS-BASEL, v. 12, n. 7, p. 12-pg., 2023-07-01. (13/07600-3, 19/04788-8, 13/07600-3, 11/13630-7, 22/07984-5, 11/23493-7)

TEIXEIRA, SAMUEL COTA; ROSINI, ALESSANDRA MONTEIRO; DE SOUZA, GUILHERME; MARTINEZ, ARYANI FELIXA; SILVA, RAFAELA JOSE; AMBROSIO, SERGIO RICARDO; VENEZIANI, RODRIGO CASSIO; BASTOS, JAIRO KENUPP; MARTINS, CARLOS HENRIQUE; BARBOSA, BELLISA FREITAS; et al. Polyalthic acid and oleoresin from Copaifera trapezifolia Hayne reduce Toxoplasma gondii growth in human villous explants, even triggering an anti-inflammatory profile. Experimental Parasitology, v. 250, p. 10-pg., 2023-05-07. (11/13630-7)

CARNEIRO, LUIZA J.; BASTOS, JAIRO K.; VENEZIANI, RODRIGO C. S.; SANTOS, MARIO F. C.; AMBROSIO, SERGIO R.. A reliable validated high-performance liquid chromatography-photodiode array detection method for quantification of terpenes in Copaifera pubiflora, Copaifera trapezifolia, and Copaifera langsdorffii oleoresins. NATURAL PRODUCT RESEARCH, v. N/A, p. 6-pg., 2022-08-22. (11/13630-7, 18/25010-2)

ROBERTO DE SOUZA, ANDERSON; STEFANY DE SOUZA CASTRO, MONA; OLIMPIO DE SOUZA, THIAGO; CASSIO SOLA VENEZIANI, RODRIGO; KENUPP BASTOS, JAIRO; RICARDO AMBROSIO, SERGIO; ALVES DOS SANTOS, RAQUEL. Kaurenoic Acid Induces Cell Cycle Arrest and Apoptosis in the MCF-7 Breast Cancer Cell Line. CHEMISTRYSELECT, v. 5, n. 38, p. 4-pg., 2020-10-15. (11/13630-7)

LEANDRO, LUIS FERNANDO; MORAES, THAIS DA SILVA; DE OLIVEIRA, POLLYANNA FRANCIELLI; ALVES, JACQUELINE MORAIS; SENEDESE, JULIANA MARQUES; OZELIN, SAULO DUARTE; RESENDE, FLAVIA APARECIDA; DE GRANDIS, RONE APARECIDO; VARANDA, ELIANA APARECIDA; BASTOS, JAIRO KENUPP; et al. Assessment of the antibacterial, cytotoxic and mutagenic potential of the phenolic-rich hydroalcoholic extract from Copaifera trapezifolia Hayne leaves. Journal of Medical Microbiology, v. 65, p. 14-pg., 2016-09-01. (12/08335-9, 11/13630-7, 12/25237-0)

VIEIRA, ROSIMARA GONCALVES LEITE; MORAES, THAIS DA SILVA; SILVA, LARISSA DE OLIVEIRA; BIANCHI, THAMIRES CHIQUINI; VENEZIANI, RODRIGO CASSIO SOLA; AMBROSIO, SERGIO RICARDO; BASTOS, JAIRO KENUPP; PIRES, REGINA HELENA; MARTINS, CARLOS HENRIQUE GOMES. In vitro studies of the antibacterial activity of Copaifera spp. oleoresins, sodium hypochlorite, and peracetic acid against clinical and environmental isolates recovered from a hemodialysis unit. ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL, v. 7, n. 1, p. 13-pg., 2018-01-24. (11/13630-7, 12/25237-0)

ABRAO, FARIZA; SILVA, THAYNA SOUZA; MOURA, CLAUDIA L.; AMBROSIO, SERGIO RICARDO; SOLA VENEZIANI, RODRIGO CASSIO; DE PAIVA, RAPHAEL E. F.; BASTOS, JAIRO KENUPP; GOMES MARTINS, CARLOS HENRIQUE. Oleoresins and naturally occurring compounds of Copaifera genus as antibacterial and antivirulence agents against periodontal pathogens. SCIENTIFIC REPORTS, v. 11, n. 1, MAR 2 2021. (18/21537-6, 16/23012-2, 11/13630-7)

MORAES, THAIS DA SILVA; LIMA, LUCAS KOZOSKI; VENEZIANI, RODRIGO CASSIO SOLA; AMBROSIO, SERGIO RICARDO; DOS SANTOS, RAQUEL ALVES; DA SILVA, JONAS JOAQUIM MANGABEIRA; RIBEIRO, GUSTAVO LIMA; BASTOS, JAIRO KENUPP; MARTINS, CARLOS HENRIQUE GOMES. In vitro Antibacterial Potential of the Oleoresin, Leaf Crude Hydroalcoholic Extracts and Isolated Compounds of the Copaifera spp. Against Helicobacter pylori. JOURNAL OF BIOLOGICALLY ACTIVE PRODUCTS FROM NATURE, v. 11, n. 2, p. 7-pg., 2021-03-04. (11/13630-7, 15/19714-9, 12/25237-0)

ABD EL-SALAM, MOHAMED A.; EL-TANBOULY, GHADA S.; BASTOS, JAIRO K.; METWALY, HEBA A.. Novel antitumor activity of the combined treatment of galloylquinic acid compounds with doxorubicin in solid Ehrlich carcinoma model via the Notch signaling pathway modulation. Life Sciences, v. 299, p. 9-pg., 2022-06-15. (11/13630-7)

DE OLIVEIRA, MARTA H.; GUSHIKEN, LUCAS F. S.; PELLIZZON, CLAUDIA H.; MANCERA, PAULO F. A.. Mathematical modelling, parameter estimation and computational simulation for skin wound healing under Copaiferalangsdorffi treatments. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, v. 199, FEB 2021. (14/23684-5, 11/13630-7, 17/17600-1)

KOVATCH, PEDRO Y.; FERREIRA, ALEXSANDRO E.; GHIZONNI, GUILHERME M. L.; AMBROSIO, SERGIO R.; CROTTI, ANTONIO E. M.; HELENO, VLADIMIR C. G.. Detailed H-1 and C-13 NMR structural assignment of ent-polyalthic acid, a biologically active labdane diterpene. Magnetic Resonance in Chemistry, v. 60, n. 2, SEP 2021. (11/13630-7)

TEIXEIRA, SAMUEL COTA; DE SOUZA, GUILHERME; BORGES, BRUNA CRISTINA; DE ARAUJO, THADIA EVELYN; ROSINI, ALESSANDRA MONTEIRO; AGUILA, FABIO ALVES; AMBROSIO, SERGIO RICARDO; SOLA VENEZIANI, RODRIGO CASSIO; BASTOS, JAIRO KENUPP; BARBOSA SILVA, MARCELO JOSE; et al. Copaifera spp. oleoresins impair Toxoplasma gondii infection in both human trophoblastic cells and human placental explants. SCIENTIFIC REPORTS, v. 10, n. 1, SEP 16 2020. (11/13630-7)

LEANDRO, LUIS FERNANDO; MORAES, THAIS DA SILVA; DE OLIVEIRA, POLLYANNA FRANCIELLI; ALVES, JACQUELINE MORAIS; SENEDESE, JULIANA MARQUES; OZELIN, SAULO DUARTE; RESENDE, FLAVIA APARECIDA; DE GRANDIS, RONE APARECIDO; VARANDA, ELIANA APARECIDA; BASTOS, JAIRO KENUPP; et al. Assessment of the antibacterial, cytotoxic and mutagenic potential of the phenolic-rich hydroalcoholic extract from Copaifera trapezifolia Hayne leaves. Journal of Medical Microbiology, v. 65, n. 9, p. 937-950, SEP 2016. (12/25237-0, 12/08335-9, 11/13630-7)

CARNEIRO, LUIZA J.; BIANCHI, THAMIRES C.; DA SILVA, JONAS J. M.; OLIVEIRA, LARISSA C.; BORGES, CARLY H. G.; LEMES, DANIELI C.; BASTOS, JAIRO K.; VENEZIANI, RODRIGO C. S.; AMBROSIO, SERGIO R.. Development and Validation of a Rapid and Reliable RP-HPLC-PDA Method for the Quantification of Six Diterpenes in Copaifera duckei, Copaifera reticulata and Copaifera multijuga Oleoresins. Journal of the Brazilian Chemical Society, v. 29, n. 4, p. 729-737, APR 2018. (16/01232-0, 14/03092-6, 11/13630-7)

DAMASCENO, JAQUELINE LOPES; ARNET, YADIRA FERNANDEZ; FORTUNATO, GIOVANNA CAPALDI; GIROTTO, LUIZA; MARENA, GABRIEL DAVI; ROCHA, BEATRIZ PATTI; RESENDE, FLAVIA APARECIDA; AMBROSIO, SERGIO RICARDO; SOLA VENEZIANI, RODRIGO CASSIO; BASTOS, JAIRO KENUPP; et al. Investigation of Safety Profile of Four Copaifera Species and of Kaurenoic Acid by Salmonella/Microsome Test. Evidence-based Complementary and Alternative Medicine, 2019. (12/25237-0, 11/13630-7)

SERGIO GUSHIKEN, LUCAS FERNANDO; HUSSNI, CARLOS ALBERTO; BASTOS, JAIRO KENUPP; ROZZA, ARIANE LEITE; BESERRA, FERNANDO PEREIRA; VIEIRA, ANA JULIA; PADOVANI, CARLOS ROBERTO; LEMOS, MARIVANE; POLIZELLO JUNIOR, MAURILIO; MANGABEIRA DA SILVA, JONAS JOAQUIM; et al. Skin Wound Healing Potential and Mechanisms of the Hydroalcoholic Extract of Leaves and Oleoresin of Copaifera langsdorffii Desf. Kuntze in Rats. Evidence-based Complementary and Alternative Medicine, 2017. (11/13630-7, 12/15092-5, 14/23684-5)

FURTADO, RICARDO ANDRADE; VILHENA BERNARDES, CRISTIANE TEIXEIRA; DA SILVA, MAURO NOGUEIRA; ZOCCAL, KARINA FURLANI; FACCIOLI, LUCIA HELENA; BASTOS, JAIRO KENUPP. Antiedematogenic Evaluation of Copaifera langsdorffii Leaves Hydroethanolic Extract and Its Major Compounds. BIOMED RESEARCH INTERNATIONAL, 2015. (11/13630-7)

DE OLIVEIRA, REJANE BARBOSA; COELHO, EDUARDO BARBOSA; RODRIGUES, MARINA REZENDE; DE MELLO COSTA-MACHADO, ANA RITA; BARRETO DE SOUSA, JOAO PAULO; BERRETTA, ANDRESA A.; BASTOS, JAIRO KENUPP. Effect of the Copaifera langsdorffii Desf. Leaf Extract on the Ethylene Glycol-Induced Nephrolithiasis in Rats. Evidence-based Complementary and Alternative Medicine, 2013. (11/13630-7)

AP SIMPLICIO, JANAINA; PERNOMIAN, LARISSA; SIMAO, MARILIA R.; CARNIO, EVELIN C.; BATALHAO, MARCELO E.; AMBROSIO, SERGIO R.; TIRAPELLI, CARLOS R.. Mechanisms underlying the vascular and hypotensive actions of the labdane ent-3-acetoxy-labda-8(17),13-dien-15-oic acid. European Journal of Pharmacology, v. 726, p. 66-76, MAR 5 2014. (11/13630-7, 10/01009-3)

SENEDESE, JULIANA MARQUES; ALVES, JACQUELINE MORAIS; DE SOUZA LIMA, ILDERCILIO MOTA; PEDROSO DE ANDRADE, ERICK AUGUSTO; FURTADO, RICARDO ANDRADE; BASTOS, JAIRO KENUPP; TAVARES, DENISE CRISPIM. Chemopreventive effect of Copaifera langsdorffii leaves hydroalcoholic extract on 1,2-dimethylhydrazine-induced DNA damage and preneoplastic lesions in rat colon. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, v. 13, JAN 7 2013. (11/13630-7)

FURTADO, RICARDO A.; GUNAHERATH, G. M. KAMAL B.; BASTOS, JAIRO K.; GUNATILAKA, A. A. LESLIE. Microbial Biotransformation of 16 alpha,17-Epoxy-ent-kaurane-19-oic acid by Beauveria sulfurescens ATCC 7159-F. NATURAL PRODUCT COMMUNICATIONS, v. 8, n. 8, p. 1041-1044, AUG 2013. (11/13630-7, 09/16081-4)

RODRIGUEZ BARDAJI, DANAE KALA; MANGABEIRA DA SILVA, JONAS JOAQUIM; BIANCHI, THAMIRES CHIQUINI; EUGENIO, DANIELE DE SOUZA; DE OLIVEIRA, POLLYANNA FRANCIELLI; LEANDRO, LUIS FERNANDO; GHISLAIN ROGEZ, HERVE LOUIS; SOLA VENEZIANNI, RODRIGO CASSIO; AMBROSIO, SERGIO RICARDO; TAVARES, DENISE CRISPIM; et al. Copaifera reticulata oleoresin: Chemical characterization and antibacterial properties against oral pathogens. Anaerobe, v. 40, p. 18-27, AUG 2016. (11/13630-7, 12/25237-0)

MOTTA, ERICK V. S.; LEMOS, MARIVANE; COSTA, JULIANA C.; BANDERO-FILHO, VILMAR C.; SASSE, ASTRID; SHERIDAN, HELEN; BASTOS, JAIRO K.. Galloylquinic acid derivatives from Copaifera langsdorffii leaves display gastroprotective activity. Chemico-Biological Interactions, v. 261, p. 145-155, JAN 5 2017. (11/13630-7, 12/09727-8, 12/01336-0)

MANGABEIRA DA SILVA, JONAS JOAQUIM; CREVELIN, EDUARDO JOSE; CARNEIRO, LUIZA JUNQUEIRA; ROGEZ, HERVE; SOLA VENEZIANI, RODRIGO CASSIO; AMBROSIO, SERGIO RICARDO; BERALDO MORAES, LUIZ ALBERTO; BASTOS, JAIRO KENUPP. Development of a validated ultra-high-performance liquid chromatography tandem mass spectrometry method for determination of acid diterpenes in Copaifera oleoresins. Journal of Chromatography A, v. 1515, p. 81-90, SEP 15 2017. (11/13630-7)

FURTADO, RICARDO ANDRADE; DE OLIVEIRA, POLLYANNA FRANCIELLI; SENEDESE, JULIANA MARQUES; OZELIN, SAULO DUARTE; RIBEIRO DE SOUZ, LARISSA DANIELA; LEANDRO, LUIS FERNANDO; DE OLIVEIRA, WENDEL LUIZ; MANGABEIRA DA SILVA, JONAS JOAQUIM; OLIVEIRA, LARISSA COSTA; ROGEZ, HERVE; et al. Assessment of genotoxic activity of oleoresins and leaves extracts of six Copaifera species for prediction of potential human risks. Journal of Ethnopharmacology, v. 221, p. 119-125, JUL 15 2018. (11/13630-7)

SENEDESE, JULIANA MARQUES; RINALDI-NETO, FRANCISCO; FURTADO, RICARDO ANDRADE; NICOLLELA, HELOIZA DINIZ; RIBEIRO DE SOUZA, LARISSA DANIELA; RIBEIRO, ARTHUR BARCELOS; FERREIRA, LUCAS SOUZA; MAGALHAES, GEORGIA MODE; CARLOS, IRACILDA ZEPPONE; MANGABEIRA DA SILVA, JONAS JOAQUIM; et al. Chemopreventive role of Copaifera reticulata Ducke oleoresin in colon carcinogenesis. BIOMEDICINE & PHARMACOTHERAPY, v. 111, p. 331-337, MAR 2019. (11/13630-7, 13/19488-3)

MOTTA, ERICK V. S.; SAMPAIO, BRUNO L.; COSTA, JULIANA C.; TEIXEIRA, SIMONE P.; BASTOS, JAIRO K.. Quantitative analysis of phenolic metabolites in Copaifera langsdorffii leaves from plants of different geographic origins cultivated under the same environmental conditions. Phytochemical Analysis, v. 30, n. 3, p. 364-372, MAY-JUN 2019. (11/13630-7, 12/01336-0)

ALVES, JESSICA APARECIDA; ABRAO, FARIZA; MORAES, THAIS DA SILVA; DAMASCENO, JAQUELINE LOPES; DOS SANTOS MORAES, MARCOS FERNANDO; SOLA VENEZIANI, RODRIGO CASSIO; AMBROSIO, SERGIO RICARDO; BASTOS, JAIRO KENUPP; DANTAS MIRANDA, MAYKER LAZARO; GOMES MARTINS, CARLOS HENRIQUE. Investigation of Copaifera genus as a new source of antimycobaterial agents. FUTURE SCIENCE OA, v. 6, n. 7, AUG 2020. (11/13630-7, 12/25237-0)

FERREIRA, ALEXSANDRO EURIPEDES; FERREIRA SOARES ROCHA, ANA CAROLINA; BASTOS, JAIRO KENUPP; GOMES HELENO, VLADIMIR CONSTANTINO. Software-assisted methodology for complete assignment of H-1 and C-13 NMR data of poorly functionalized molecules: The case of the chemical marker diterpene ent-copalic acid. Journal of Molecular Structure, v. 1228, MAR 15 2021. (11/13630-7)

DE SEIXAS, ARTHUR TAVARES; GALLANI, SILVIA UMEDA; NORONHA, LEILANE DA SILVA; MANGABEIRA SILVA, JONAS JOAQUIM; RIZZATO PASCHOAL, JONAS AUGUSTO; BASTOS, JAIRO KENUPP; RAMOS VALLADAO, GUSTAVO MORAES. Copaiferaoleoresins as a novel natural product against acanthocephalan in aquaculture: Insights in the mode of action and toxicity. AQUACULTURE RESEARCH, v. 51, n. 11, AUG 2020. (11/13630-7)

OLIVEIRA, LARISSA COSTA; PORTO, THIAGO SOUZA; COLMANETTE JUNIOR, ARTHUR HENRIQUE; CONCEICAO SANTOS, MARIO FERREIRA; RAMOS, HENRIQUE PEREIRA; BRAUN, GLAUCIA HOLLAENDER; DE LIMA PAULA, LUCAS ANTONIO; BASTOS, JAIRO KENUPP; JACOMETTI CARDOSO FURTADO, NIEGE ARACARI; TAME PARREIRA, RENATO LUIS; et al. Schistosomicidal activity of kaurane, labdane and clerodane-type diterpenes obtained by fungal transformation. Process Biochemistry, v. 98, p. 34-40, NOV 2020. (11/13630-7, 11/21638-8, 17/02592-3)

RIBEIRO, VICTOR PENA; ARRUDA, CAROLINE; MANGABEIRA DA SILVA, JONAS JOAQUIM; ALDANA MEJIA, JENNYFER ANDREA; JACOMETTI CARDOSO FURTADO, NIEGE ARACARI; BASTOS, JAIRO KENUPP. Use of spinning band distillation equipment for fractionation of volatile compounds of Copaifera oleoresins for developing a validated gas chromatographic method and evaluating antimicrobial activity. BIOMEDICAL CHROMATOGRAPHY, v. 33, n. 2, FEB 2019. (11/13630-7)

CRUZ DE CARVALHO, TATIANE; DE OLIVEIRA SILVA, ELIANE; SOARES, GILBERTO AUGUSTO; PARREIRA, RENATO LUIS TAME; AMBROSIO, SERGIO RICARDO; JACOMETTI CARDOSO FURTADO, NIEGE ARACARI. Fungal biocatalysts for labdane diterpene hydroxylation. Bioprocess and Biosystems Engineering, v. 43, n. 6, FEB 2020. (11/13630-7, 16/25201-7, 12/01766-4)

CHIBAS, LENIHER CASTAN; CINTRA, PRISCILA PAVINI; MOREIRA, MONIQUE RODRIGUES; GOULART, MIRIAN OLIVEIRA; AMBROSIO, SERGIO RICARDO; SOLA VENEZIANI, RODRIGO CASSIO; BASTOS, JAIRO KENUPP; DOS SANTOS, RAQUEL ALVES. Polyalthic Acid in Polymeric Nanoparticles Causes Selective Growth Inhibition and Genotoxicity in MCF-7 Cells. NATURAL PRODUCT COMMUNICATIONS, v. 14, n. 4, APR 2019. (11/13630-7, 14/12465-0)

CANO, BRUNO LIMONTI; MOREIRA, MONIQUE RODRIGUES; GOULART, MIRIAN OLIVEIRA; DOS SANTOS GONCALVES, NATALIA; SOLA VENEZIANI, RODRIGO CASSIO; BASTOS, JAIRO KENUPP; AMBROSIO, SERGIO RICARDO; DOS SANTOS, RAQUEL ALVES. Comparative study of the cytotoxicity and genotoxicity of kaurenoic acid and its semi-synthetic derivatives methoxy kaurenoic acid and kaurenol in CHO-K1cells. Food and Chemical Toxicology, v. 102, p. 102-108, APR 2017. (11/13630-7)

SILVA, ALINE N.; SOARES, ANA CAROLINA F.; CABRAL, MIRELA M. W.; DE ANDRADE, ALEXR. P.; DA SILVA, MARILZA B. M.; MARTINS, CARLOS H. G.; VENEZIANI, RODRIGO C. S.; AMBROSIO, SERGIOR.; BASTOS, JAIRO K.; HELENO, VLADIMIR C. G.. Antitubercular Activity Increase in Labdane Diterpenes from Copaifera Oleoresin through Structural Modification. Journal of the Brazilian Chemical Society, v. 28, n. 6, p. 1106-1112, JUN 2017. (11/13630-7, 09/09491-1)

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MIZUNO, CASSIA S.; SOUZA, ARIANA B.; TEKWANI, BABU L.; AMBROSIO, SERGIO R.; VENEZIANI, RODRIGO C. S.. Synthesis and biological evaluation of polyalthic acid derivatives for the treatment of neglected diseases. Bioorganic & Medicinal Chemistry Letters, v. 25, n. 23, p. 5529-5531, DEC 1 2015. (11/13630-7, 11/23493-7)

GONCALVES DIAS, FERNANDA GOSUEN; JORGE, ADRIANA TORRECILHAS; PEREIRA, LUCAS DE FREITAS; FURTADO, RICARDO ANDRADE; AMBROSIO, SERGIO RICARDO; BASTOS, JAIRO KENUPP; RAMOS, SALVADOR BOCCALETTI; CHAHUD, FERNANDO; GOSUEN GONCALVES DIAS, LUIS GUSTAVO; HONSHO, CRISTIANE DOS SANTOS; et al. Use of Copaifera multijuga for acute corneal repair after chemical injury: A clinical, histopathological and toxicogenetic study. BIOMEDICINE & PHARMACOTHERAPY, v. 96, p. 1193-1198, DEC 2017. (11/13630-7)

ALVES, JACQUELINE MORAIS; LEANDRO, LUIS FERNANDO; SENEDESE, JULIANA MARQUES; DE CASTRO, PAMELA TINTI; PEREIRA, DAIANE ELEUTERIO; RESENDE, FLAVIA APARECIDA; CAMPOS, DEBORA LEITE; MANGABEIRA DA SILVA, JONAS JOAQUIM; VARANDA, ELIANA APARECIDA; BASTOS, JAIRO KENUPP; et al. Antigenotoxicity properties of Copaifera multijuga oleoresin and its chemical marker, the diterpene (-)-copalic acid. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, v. 81, n. 5, p. 116-129, 2018. (09/17237-8, 11/13630-7)

LEITE VIEIRA, ROSIMARA GONCALVES; MORAES, THAIS DA SILVA; SILVA, LARISSA DE OLIVEIRA; BIANCHI, THAMIRES CHIQUINI; SOLA VENEZIANI, RODRIGO CASSIO; AMBROSIO, SERGIO RICARDO; BASTOS, JAIRO KENUPP; PIRES, REGINA HELENA; GOMES MARTINS, CARLOS HENRIQUE. In vitro studies of the antibacterial activity of Copaifera spp. oleoresins, sodium hypochlorite, and peracetic acid against clinical and environmental isolates recovered from a hemodialysis unit. ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL, v. 7, JAN 24 2018. (11/13630-7, 12/25237-0)

ARRUDA, CAROLINE; ALDANA MEJIA, JENNYFER ANDREA; RIBEIRO, VICTOR PENA; GAMBETA BORGES, CARLY HENRIQUE; GOMES MARTINS, CARLOS HENRIQUE; SOLA VENEZIANI, RODRIGO CASSIO; AMBROSIO, SERGIO RICARDO; BASTOS, JAIRO KENUPP. Occurrence, chemical composition, biological activities and analytical methods on Copaifera genus-A review. BIOMEDICINE & PHARMACOTHERAPY, v. 109, p. 1-20, JAN 2019. (11/13630-7)

ABD EL-SALAM, MOHAMED; EL-TANBOULY, GHADA; BASTOS, JAIRO; METWALY, HEBA. Suppression of VEGF and inflammatory cytokines, modulation of Annexin A1 and organ functions by galloylquinic acids in breast cancer model. SCIENTIFIC REPORTS, v. 13, n. 1, p. 18-pg., 2023-07-28. (11/13630-7)

AL-MADBOLY, LAMIAA A.; ABD EL-SALAM, MOHAMED A.; BASTOS, JAIRO K.; EL-SHORBAGY, SAFINAZ H.; EL-MORSI, RASHA M.. Novel Preclinical Study of Galloylquinic Acid Compounds from Copaifera lucens with Potent Antifungal Activity against Vaginal Candidiasis Induced in a Murine Model via Multitarget Modes of Action. MICROBIOLOGY SPECTRUM, v. N/A, p. 24-pg., 2022-08-16. (11/13630-7)

SOUSA, INGRID P.; DE SOUSA TEIXEIRA, MARIA, V; FREITAS, JOLINDO A.; FERREIRA, ANTONIO G.; PIRES, LOREN M.; SANTOS, RAQUEL A.; GOMES HELENO, VLADIMIR CONSTANTINO; CARDOSO FURTADO, NIEGE A. JACOMETTI. Production of More Potent Anti-Candida Labdane Diterpenes by Biotransformation Using Cunninghamella elegans. CHEMISTRY & BIODIVERSITY, v. 19, n. 3, p. 9-pg., 2022-02-19. (11/13630-7, 16/25201-7)

CECHINEL-ZANCHETT, CAMILE CECCONI; BOLDA MARIANO, LUISA NATHAPRIMELIA; BOEING, THAISE; DA COSTA, JULIANA DE CARVALHO; DA SILVA, LUISA MOTA; BASTOS, JAIRO K.; CECHINEL-FILHO, VALDIR; DE SOUZA, PRISCILA. Diuretic and Renal Protective Effect of Kaempferol 3-O-Alpha-L-rhamnoside (Afzelin) in Normotensive and Hypertensive Rats. Journal of Natural Products, v. 83, n. 6, p. 1980-1989, JUN 26 2020. (11/13630-7)

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SIMARO, GUILHERME VENANCIO; LEMOS, MARIVANE; DA SILVA, JONAS JOAQUIM MANGABEIRA; RIBEIRO, VICTOR PENA; ARRUDA, CAROLINE; SCHNEIDER, AYDA HENRIQUES; WANDERLEY, CARLOS WAGNER DE SOUZA; CARNEIRO, LUIZA JUNQUEIRA; MARIANO, ROBERTA LOPES; AMBROSIO, SERGIO RICARDO; et al. Antinociceptive and anti-inflammatory activities of Copaifera pubiflora Benth oleoresin and its major metabolite ent-hardwickiic acid. Journal of Ethnopharmacology, v. 271, MAY 10 2021. (11/13630-7)

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