Chemical validation and in vitro antitumor activity of secondary metabolites obtained from the oleoresin of Copaifera multijuga

• Grant number: 14/03092-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: July 01, 2014
• End date: February 29, 2016
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Sergio Ricardo Ambrosio
• Grantee: Luiza Junqueira Carneiro
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
• Associated research grant: 11/13630-7 - Chemical and pharmacological validation of extracts and active compounds of Copaifera species, AP.TEM

Abstract

Despite of the wide folk use of copaiba oil resin by the Brazilians since XIX century and several developed studies corroborating many of its ethnopharmacological uses, as well as its production being around 800 tons per year, there is a great need to fully determine the following parameters: phytochemical, pharmacological, toxicological and clinical studies, aiming to guarantee safety, efficacy and quality, which are mandatory for developing new phytomedicines. In this sense, the goal of this proposal is to undertake the chemical validation of the oleoresin of Copaifera multijuga and to evaluate the antitumor activity (in vitro) of the major secondary metabolites isolated from this natural source, aiming to better understand the use of oleoresin from species of Copaifera by the Brazilian population as antitumoral agents. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CARNEIRO, LUIZA J.; BIANCHI, THAMIRES C.; DA SILVA, JONAS J. M.; OLIVEIRA, LARISSA C.; BORGES, CARLY H. G.; LEMES, DANIELI C.; BASTOS, JAIRO K.; VENEZIANI, RODRIGO C. S.; AMBROSIO, SERGIO R.. Development and Validation of a Rapid and Reliable RP-HPLC-PDA Method for the Quantification of Six Diterpenes in Copaifera duckei, Copaifera reticulata and Copaifera multijuga Oleoresins. Journal of the Brazilian Chemical Society, v. 29, n. 4, p. 729-737, APR 2018. (16/01232-0, 14/03092-6, 11/13630-7)

CARNEIRO, LUIZA J.; BIANCHI, THAMIRES C.; DA SILVA, JONAS J. M.; OLIVEIRA, LARISSA C.; BORGES, CARLY H. G.; LEMES, DANIELI C.; BASTOS, JAIRO K.; VENEZIANI, RODRIGO C. S.; AMBROSIO, SERGIO R.. Development and Validation of a Rapid and Reliable RP-HPLC-PDA Method for the Quantification of Six Diterpenes in Copaifera duckei, Copaifera reticulata and Copaifera multijuga Oleoresins. Journal of the Brazilian Chemical Society, v. 29, n. 4, p. 9-pg., 2018-04-01. (14/03092-6, 11/13630-7, 16/01232-0)