Many plants are sources of active secondary metabolites that can be employed more directly as phytomedicines or in their isolated forms as drugs themselves, or even as semi-synthethic precursors of new drugs. In this sense, it is important to highlight that quality control and standardization of plants raw materials are a central issue in successful strategies that use natural products for the development of new drugs, as well as to ensure the quality of the already available ones. The Copaifera langsdorfii oleoresin is a natural product very valuable for pharmaceutical companies due to its antiinflammatory, analgesic and antimicrobial potential. In addition, its value is reinforced by its use in fragrance, cosmetic and varnishes industry. It is very common to find out in the market oleoresins whose origin is not well established. Due to this problem, analytical methodologies used for the qualitative and quantitative characterization of C. langsdorfii oleoresin play a key role in the standardization and quality insurance of this material. In this project, it is proposed the isolation of analytical standards and the development and validation of an analytical methodology by High Performance Liquid Chromatography (HPLC) in order to allow the direct analysis of this oleoresin, avoiding the chemical derivatization step, which is commonly found in the current used Gas Chromatography methods (GC). In this sense, a HPLC direct analysis of C. langsdorfii oleoresin will be more practical and fast than the GC approach.
News published in Agência FAPESP Newsletter about the scholarship: