The adenosinergic signaling in the pathogenesis and treatment of multiple sclerosis

Autor(es)

Duarte-Silva, Eduardo ; Ulrich, Henning ; Oliveira-Giacomelli, Agatha ; Hartung, Hans-Peter ; Meuth, Sven G. ; Peixoto, Christina Alves

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN IMMUNOLOGY; v. 13, p. 10-pg., 2022-07-28.

Resumo

Multiple sclerosis (MS) is a highly disabling, progressive neurodegenerative disease with no curative treatment available. Although significant progress has been made in understanding how MS develops, there remain aspects of disease pathogenesis that are yet to be fully elucidated. In this regard, studies have shown that dysfunctional adenosinergic signaling plays a pivotal role, as patients with MS have altered levels adenosine (ADO), adenosine receptors and proteins involved in the generation and termination of ADO signaling, such as CD39 and adenosine deaminase (ADA). We have therefore performed a literature review regarding the involvement of the adenosinergic system in the development of MS and propose mechanisms by which the modulation of this system can support drug development and repurposing. (AU)

• Processo FAPESP: 18/07366-4 - Receptores de purinas e cininas como alvos de estudo e intervenção terapêutica em doenças neurológicas
• Beneficiário: Alexander Henning Ulrich
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/08426-0 - Alcalóides indólicos, subprodutos do processamento de Maqui (Aristotelia chilensis) como aditivos alimentares no tratamento da Doença de Alzheimer
• Beneficiário: Alexander Henning Ulrich
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 19/26852-0 - Estudo do antagonismo de receptores purinérgicos no processo inflamatório e ativação microglial em modelos in vivo e in vitro de Doença de Parkinson
• Beneficiário: Ágatha Oliveira Giacomelli
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado