| Texto completo | |
| Autor(es): Mostrar menos - |
Yukuyama, Megumi Nishitani
;
Ferreira Guimaraes, Lara Mendes
;
Segovia, Rafael Scheliga
;
Lameu, Claudiana
;
Barros de Araujo, Gabriel Lima
;
Lobenberg, Raimar
;
de Souza, Aline
;
Bazan Henostroza, Mirla Anali
;
Folchini, Beatriz Rabelo
;
Peroni, Camilla Midori
;
Saito Miyagi, Mariana Yasue
;
Oliveira, Isabela Fernandes
;
Rinaldi Alvarenga, Jose Fernando
;
Fiamoncini, Jarlei
;
Bou-Chacra, Nadia Araci
Número total de Autores: 15
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY; v. 78, p. 10-pg., 2022-11-12. |
| Resumo | |
Malignant wounds (MWs) affect up to 15% of advanced stage cancer patients, causing detrimental effects such as tissue deformity and extreme malodor, affecting the social and psychological quality of life of these patients. Although treating MW is mandatory to prevent infections and reduce wound healing time, this disease has often been overlooked by researchers. For the first time, we propose a new alternative MW treatment for oral administration using high-oil-content flubendazole (FLZ) loaded in nanoemulsions, prepared by the D-phase emulsification process. We performed in vivo tests on the A549 xenograft murine model and compared FLZ in suspension, drug-free nanoemulsion, FLZ-loaded nanoemulsion containing oil derived from linoleic acid, and FLZ-loaded nanoemulsion containing mixture of oils. Mice treated by gavage three times a week with FLZ in suspension, drug-free nanoemulsion, and FLZ-loaded nanoemulsion with mixed oil, presented MW emergence in 20-40% of the cases at different time intervals and extents. However, mice treated with FLZ-loaded nanoemulsion containing only the oil derived from linoleic acid presented MW emergence in 0% of cases, even after 80 days of treatment. Thus, we observed a positive synergy between the drug FLZ and the oil derived from linoleic acid in the treatment of MW. Discussions on the mechanism of action of this oil and the drug are intensively described in this article. We present such FLZ-loaded nanoemulsion as a promising prevention and treatment solution for greater patient compliance and lower adverse effects. (AU) | |
| Processo FAPESP: | 18/22713-2 - Estudo do reposicionamento do flubendazol para o tratamento de câncer de pulmão e meningoencefalite empregando nanossistema lipídico oral |
| Beneficiário: | Megumi Nishitani Yukuyama |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 20/15981-0 - Estudo do reposicionamento do flubendazol para o tratamento de câncer de pulmão e meningoencefalite empregando nanossistema lipídico oral |
| Beneficiário: | Megumi Nishitani Yukuyama |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Doutorado |
| Processo FAPESP: | 19/04998-2 - Formulações nanocristalinas e dispersões sólidas amorfas para a melhoria de terapias antitumorais |
| Beneficiário: | Gabriel Lima Barros de Araujo |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/19128-2 - Mecanismos de metástase de tumores infantis para a medula óssea |
| Beneficiário: | Claudiana Lameu |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |