Mnemonic strategy training modulates functional connectivity at rest in mild cognitive impairment: Results from a randomized controlled trial

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Simon, Sharon Sanz ; Hampstead, Benjamin M. ; Nucci, Mariana P. ; Ferreira, Luiz Kobuti ; Duran, Fabio L. S. ; Fonseca, Luciana M. ; Martin, Maria da Graca M. ; Avila, Renata ; Porto, Fabio H. G. ; Brucki, Sonia M. D. ; Martins, Camila B. ; Tascone, Lyssandra S. ; Amaro Jr, Edson ; Busatto, Geraldo F. ; Bottino, Cassio M. C.

• Tipo de documento: Artigo Científico
• Fonte: ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS; v. 6, n. 1, p. 12-pg., 2020-01-01.

Resumo

Introduction: Mnemonic strategy training (MST) has been shown to improve cognitive performance and increase brain activation in those with mild cognitive impairment (MCI). However, little is known regarding the effects of MST on functional connectivity (FC) at rest. The aim of the present study was to investigate the MST focused on face-name associations effect on resting-state FC in those with MCI Methods: Twenty-six amnestic MCI participants were randomized in MST (N = 14) and Education Program (active control; N = 12). Interventions occurred twice a week over two consecutive weeks (ie, four sessions). Resting-state functional magnetic resonance imaging was collected at pre- and post-intervention. Regions of interest (ROIs) were selected based on areas that previously showed task-related activation changes after MST. Changes were examined through ROI-to-ROI analysis and significant results were corrected for multiple comparisons. Results: At post-intervention, only the MST group showed increased FC, whereas the control group showed decreased or no change in FC. After MST, there was an increased FC between the left middle temporal gyrus and right orbitofrontal cortex. In addition, a time-by-group interaction indicated that the MST group showed greater increased FC between the right inferior frontal gyrus and left brain regions, such as fusiform gyrus, temporal pole, and orbitofrontal cortex relative to controls. Discussion: MST enhanced FC in regions that are functionally relevant for the training; however, not in all ROIs investigated. Our findings suggest that MST-induced changes are reflected in task-specific conditions, as previously reported, but also in general innate connectivity. Our results both enhance knowledge about the mechanisms underlying MST effects and may provide neurophysiological evidence of training transfer. (AU)

• Processo FAPESP: 12/51699-1 - Treino de memória episódica para associação de faces e nomes no comprometimento cognitivo leve amnéstico: desfecho em medidas cognitivas e ressonância magnética funcional
• Beneficiário: Cássio Machado de Campos Bottino
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/50010-0 - Prevenção e tratamento da depressão em idosos: um estudo de base populacional
• Beneficiário: Geraldo Busatto Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 12/50329-6 - Neurociência translacional da doença de Alzheimer: estudos pré-clínicos e clínicos do peptídeo b-amiloide e outros biomarcadores
• Beneficiário: Geraldo Busatto Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático