A Review of Omics Studies on Arboviruses: Alphavirus, Orthobunyavirus and Phlebovirus

Autor(es)

Peinado, Rafaela dos S. ; Eberle, Raphael J. ; Arni, Raghuvir K. ; Coronado, Monika A.

• Tipo de documento: Artigo Científico
• Fonte: Viruses-Basel; v. 14, n. 10, p. 28-pg., 2022-10-01.

Resumo

Since the intricate and complex steps in pathogenesis and host-viral interactions of arthropod-borne viruses or arboviruses are not completely understood, the multi-omics approaches, which encompass proteomics, transcriptomics, genomics and metabolomics network analysis, are of great importance. We have reviewed the omics studies on mosquito-borne viruses of the Togaviridae, Peribuyaviridae and Phenuiviridae families, specifically for Chikungunya, Mayaro, Oropouche and Rift Valley Fever viruses. Omics studies can potentially provide a new perspective on the pathophysiology of arboviruses, contributing to a better comprehension of these diseases and their effects and, hence, provide novel insights for the development of new antiviral drugs or therapies. (AU)

• Processo FAPESP: 20/08615-8 - Exosítios de proteínas, sítios crípticos e moonlighting: identificação, mapeamento funcional e efeitos de alteração estrutural
• Beneficiário: Raghuvir Krishnaswamy Arni
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 20/03639-6 - Metabolômica de RMN: perfis metabólicos de células Vero infectadas com Zika e Chikungunya e inibição por wedelolactona
• Beneficiário: Rafaela dos Santos Peinado
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto