Cardiotoxicity of pyrethroids: molecular mechanisms and therapeutic options for acute and long-term toxicity

Autor(es)

Marques, Leisiane P. ; Joviano-Santos, Julliane, V ; Souza, Diego S. ; Santos-Miranda, A. ; Roman-Campos, D.

• Tipo de documento: Artigo Científico
• Fonte: BIOCHEMICAL SOCIETY TRANSACTIONS; v. N/A, p. 15-pg., 2022-10-31.

Resumo

Pyrethroids (PY) are synthetic pesticides used in many applications ranging from largescale agriculture to household maintenance. Their classical mechanisms of action are associated with binding to the sodium channel of insect neurons, disrupting its inactivation, ensuring their use as insecticides. However, PY can also lead to toxicity in vertebrates, including humans. In most toxicological studies, the impact of PY on heart function is neglected. Acute exposure to a high dose of PY causes enhancement of the late sodium current (INaL), which impairs the action potential waveform and can cause severe cardiac arrhythmias. Moreover, long-term, low-dose exposure to PY displays oxidative stress in the heart, which could induce tissue remodeling and impairment. Isolated and preliminary evidence supports that, for acute exposure to PY, an antiarrhythmic therapy with ranolazine (an INaL blocker), can be a promising therapeutic approach. Besides, heart tissue remodeling associated with low doses and long-term exposure to PY seems to benefit from antioxidant therapy. Despite significant leaps in understanding the mechanical details of PY intoxication, currently, few studies are focusing on the heart. In this review, we present what is known and what are the gaps in the field of cardiotoxicity induced by PY. (AU)

• Processo FAPESP: 21/15122-0 - Cardiotoxicidade induzida pelo pesticida tebuconazol em camundongos: da concepção a vida adulta
• Beneficiário: Leisiane Pereira Marques
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 21/05584-7 - Avaliação da toxicidade aguda e crônica ao coração e ao cérebro expostos a pesticidas encontrados na água potável do Brasil
• Beneficiário: Danilo Roman Campos
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2
• Processo FAPESP: 19/18918-0 - Participação do óxido nítrico nas arritmias cardíacas durante o Hipotireoidismo
• Beneficiário: Diego Santos de Souza
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado