Circular RNAs as a Diagnostic and Therapeutic Target in Cardiovascular Diseases

Autor(es)

Joaquim, Victor Hugo Antonio ; Pereira, Noemy Pinto ; Fernandes, Tiago ; Oliveira, Edilamar Menezes

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 24, n. 3, p. 16-pg., 2023-02-01.

Resumo

Circular RNAs (circRNAs) are a family of noncoding RNAs (ncRNAs) that are endogenous and widely distributed in different species, performing several functions, mainly their association with microRNAs (miRNAs) and RNA-binding proteins. CVDs remain the leading cause of death worldwide; therefore, the development of new therapies and strategies, such as gene therapies or nonpharmacological therapies, with low cost, such as physical exercise, to alleviate these diseases is of extreme importance for society. With increasing evidence of ncRNA participating in the progression of CVDs, several studies have reported these RNAs as promising targets for diagnosis and treatment. There are several studies of CVDs and the role of miRNAs and lncRNAs; however, little is known about the new class of RNAs, called circRNAs, and CVDs. In this mini review, we focus on the mechanisms of circRNAs and CVDs. (AU)

• Processo FAPESP: 15/22814-5 - Câncer e coração: novos paradigmas de diagnóstico e tratamento
• Beneficiário: Carlos Eduardo Negrão
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 22/00531-5 - Novas terapias para infarto do miocárdio: papel do treinamento físico e novos RNAs
• Beneficiário: Edilamar Menezes de Oliveira
• Modalidade de apoio: Bolsas no Exterior - Pesquisa
• Processo FAPESP: 18/22579-4 - MicroRNAs exossômicos como biomarcadores circulantes e mediadores do efeito cardioprotetor em pacientes submetidos a terapias contra o câncer
• Beneficiário: Edilamar Menezes de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular