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Risk Factors Associated with Mortality in Hospitalized Patients with COVID-19 during the Omicron Wave in Brazil

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Autor(es):
Colnago, Marilaine ; Benvenuto, Giovana A. ; Casaca, Wallace ; Negri, Rogerio G. ; Fernandes, Eder G. ; Cuminato, Jose A.
Número total de Autores: 6
Tipo de documento: Artigo Científico
Fonte: BIOENGINEERING-BASEL; v. 9, n. 10, p. 11-pg., 2022-10-01.
Resumo

Considering the imminence of new SARS-CoV-2 variants and COVID-19 vaccine availability, it is essential to understand the impact of the disease on the most vulnerable groups and those at risk of death from the disease. To this end, the odds ratio (OR) for mortality and hospitalization was calculated for different groups of patients by applying an adjusted logistic regression model based on the following variables of interest: gender, booster vaccination, age group, and comorbidity occurrence. A massive number of data were extracted and compiled from official Brazilian government resources, which include all reported cases of hospitalizations and deaths associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Brazil during the "wave" of the Omicron variant (BA.1 substrain). Males (1.242; 95% CI 1.196-1.290) aged 60-79 (3.348; 95% CI 3.050-3.674) and 80 years or older (5.453; 95% CI 4.966-5.989), and hospitalized patients with comorbidities (1.418; 95% CI 1.355-1.483), were more likely to die. There was a reduction in the risk of death (0.907; 95% CI 0.866-0.951) among patients who had received the third dose of the anti-SARS-CoV-2 vaccine (booster). Additionally, this big data investigation has found statistical evidence that vaccination can support mitigation plans concerning the current scenario of COVID-19 in Brazil since the Omicron variant and its substrains are now prevalent across the entire country. (AU)

Processo FAPESP: 21/03328-3 - Desenvolvimento de novas metodologias e soluções tecnológicas inteligentes em segmentação de imagens digitais e enfrentamento da COVID-19
Beneficiário:Wallace Correa de Oliveira Casaca
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/07375-0 - CeMEAI - Centro de Ciências Matemáticas Aplicadas à Indústria
Beneficiário:Francisco Louzada Neto
Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Processo FAPESP: 21/01305-6 - Avanços teóricos em detecção de anomalias e construção de sistemas de monitoramento ambiental
Beneficiário:Rogério Galante Negri
Modalidade de apoio: Auxílio à Pesquisa - Regular