| Texto completo | |
| Autor(es): Mostrar menos - |
Garcia de Figueiredo, Mario Luis
;
Williams, Evan P.
;
Jonsson, Colleen B.
;
Khan, Mohd Jaseem
;
Teixeira Nunes, Marcio Roberto
;
Silva de Lima, Clayton Pereira
;
Moraes Figueiredo, Luiz Tadeu
;
Farias Costa, Monica Regina
;
Gomes Mourao, Maria Paula
;
Guimaraes Lacerda, Marcus Vinicius
;
Aquino, Victor Hugo
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ARCHIVES OF VIROLOGY; v. 167, n. 11, p. 12-pg., 2022-07-16. |
| Resumo | |
Arthropod-borne viruses (arboviruses) are a significant public health threat, especially in tropical and subtropical regions. More than 150 arboviruses can cause febrile illness following infection in humans. The Brazilian Amazon region has the highest number of arboviruses detected worldwide. In addition to arboviruses, malaria, caused by Plasmodium vivax, is endemic in the Amazon. Patients with malaria and arboviral disease frequently show similar clinical presentation and laboratory findings, making the diagnosis of the cause of the infection challenging. The aim of this study was to evaluate the potential for viral infections in patients with suspected malaria but without Plasmodium infection in the Brazilian Amazon. We recruited 200 subjects with suspected malaria in Manaus, Brazil. First, we tested for arboviruses in serum samples from 124 of the 200 participants using an arbovirus DNA microarray platform, which did not detect any virus. Then, we mixed the serum samples of the other 76 participants in 10 pools and subjected them to next-generation sequencing. Analysis of the sequencing data revealed the presence of only one arbovirus (Zika virus) in one sample pool. This analysis also detected the presence of primate erythroparvovirus 1 and pegivirus C. These results suggest that arboviruses are not the most frequent viral infections in patients with suspected malaria but without Plasmodium infection in the metropolitan region of Manaus. Implementation of specific viral surveillance tests will help in the early detection of viruses with epidemic potential. (AU) | |
| Processo FAPESP: | 15/04882-3 - Identificação e caracterização de vírus causadores de doenças febris transmitidos por artrópodes e roedores na região de Porto Velho, Rondônia |
| Beneficiário: | Mario Luis Garcia de Figueiredo |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 17/09194-3 - Vigilância de vírus transmitidos por artrópodes (arbovírus) |
| Beneficiário: | Victor Hugo Aquino Quintana |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |