A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine

Autor(es)

Gimenes, G. M. ; Santana, G. O. ; Scervino, M. V. M. ; Curi, R. ; Pereira, J. N. B.

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 55, n. 1, p. 10-pg., 2022-01-01.

Resumo

The Goto-Kakizaki (GK) rat is a non-obese experimental model of type 2 diabetes mellitus (T2DM) that allows researchers to monitor diabetes-induced changes without jeopardizing the effects of obesity. This rat strain exhibits notable gastrointestinal features associated with T2DM, such as marked alterations in intestinal morphology, reduced intestinal motility, slow transit, and modified microbiota compared to Wistar rats. The primary treatments for diabetic patients include administration of hypoglycemic agents and insulin, and lifestyle changes. Emerging procedures, including alternative therapies, metabolic surgeries, and modulation of the intestinal microbiota composition, have been shown to improve the diabetic state of GK rats. This review describes the morpho-physiological diabetic-associated features of the gastrointestinal tract (GIT) of GK rats. We also describe promising strategies, e.g., metabolic surgery and modulation of gut microbiota composition, used to target the GIT of this animal model to improve the diabetic state. (AU)

• Processo FAPESP: 18/09868-7 - Mecanismos celulares e moleculares envolvidos na resistência à insulina e inflamação em ratos Wistar obesos e Goto-Kakizaki magros: causas e associações com dieta e exercício físico
• Beneficiário: Rui Curi
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/19097-0 - Envolvimento da inflamação na resposta hipertrófica do músculo esquelético em ratos com Diabetes Mellitus Tipo I
• Beneficiário: Maria Vitoria Martins Scervino
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 19/01942-6 - Caracterização neuroquímica do plexo mioentérico do intestino de ratos Goto-Kakizaki
• Beneficiário: Gabriela Mandu Gimenes
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica