| Texto completo | |
| Autor(es): Mostrar menos - |
Silva-Reis, Anamei
;
Rodrigues Brandao-Rangel, Maysa Alves
;
Moraes-Ferreira, Renilson
;
Gibson Goncalves-Alves, Thiago
;
Hugo Souza-Palmeira, Victor
;
Cristina Aquino-Santos, Helida
;
Lacerda Bachi, Andre Luis
;
Franco de Oliveira, Luis Vicente
;
Brandao Lopes-Martins, Rodrigo Alvaro
;
Oliveira-Silva, Iranse
;
Albertini, Regiane
;
Frison, Claudio Ricardo
;
Vieira, Rodolfo P.
Número total de Autores: 13
|
| Tipo de documento: | Artigo Científico |
| Fonte: | FRONTIERS IN PHYSIOLOGY; v. 13, p. 14-pg., 2022-09-07. |
| Resumo | |
Background: Obesity impairs lung function and mechanics and leads to low-grade inflammation, but the effects of combined physical exercise (CPE) on that are unknown. Methods: We investigated the effects of 12 weeks of combined physical exercise (aerobic + resistance training), in non-obese (n = 12), overweight (n = 17), and obese grade I (n = 11) women. Lung function and lung mechanics were evaluated. The systemic immune response was evaluated by whole blood analysis and biomarker measurements, while pulmonary fibrotic biomarkers were evaluated in the breath condensate. Result: CPE improved forced vital capacity (FVC) % (p < 0.001) and peak expiratory flow (PEF) % (p < 0.0003) in the obese group; resistance of the respiratory system (R5Hz) in non-obese (p < 0.0099), overweight (p < 0.0005), and obese (p < 0.0001) groups; resistance of proximal airways (R20Hz) in non-obese (p < 0.01), overweight (p < 0.0009), and obese (p < 0.0001) groups; resistance of distal airways (R5Hz-R20Hz) in non-obese (p < 0.01), overweight (p < 0.0012), and obese (p < 0.0001) groups; reactance of the respiratory system (X5Hz) in non-obese (p < 0.01), overweight (p < 0.0006), and obese (p < 0.0005) groups; impedance of the respiratory system (Z5Hz) in non-obese (p < 0.0099), overweight (p < 0.0005), and obese (p < 0.0001) groups; central resistance (RCentral) in non-obese (p < 0.01), overweight (p < 0.001), and obese (p < 0.0003) groups; and the peripheral resistance (RPeripheral) in non-obese (p < 0.03), overweight (p < 0.001), and obese (p < 0.0002) groups. CPE reduced the pro-fibrotic IGF-1 levels in BC in overweight (p < 0.0094) and obese groups (p < 0.0001) and increased anti-fibrotic Klotho levels in BC in obese (p < 0.0001) groups, and reduced levels of exhaled nitric oxide in overweight (p < 0.03) and obese (p < 0.0001) groups. Conclusion: CPE improves lung function, mechanics, and pulmonary immune response in overweight and obese grade I women by increasing anti-fibrotic protein Klotho and reducing pro-fibrotic IGF-1. (AU) | |
| Processo FAPESP: | 19/05739-0 - Papel das cininas nos efeitos anti-inflamatórios do treinamento aeróbio em modelo experimental de Asma |
| Beneficiário: | Maysa Alves Rodrigues Brandão Rangel |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 20/03994-0 - Proteínas pro e anti-fibróticas e asma: existe uma correlação entre seus níveis com a inflamação e resistência das vias aéreas? |
| Beneficiário: | Victor Hugo Souza Palmeira |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 19/11244-4 - Efeitos do treinamento físico combinado sobre a mecânica e função pulmonar e sobre a resposta imune pulmonar e sistêmica de mulheres obesas |
| Beneficiário: | Anamei Silva Reis |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 19/11008-9 - O papel do treinamento físico nas respostas pró e anti-fibróticas pulmonares de indivíduos asmáticos |
| Beneficiário: | Renilson Moraes Ferreira |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 12/15165-2 - Papel da sinalização purinérgica e da sinalização SOCS-JAK-STAT nos efeitos antiinflamatórios do treinamento aeróbio em modelos experimentais de asma e em indivíduos asmáticos |
| Beneficiário: | Rodolfo de Paula Vieira |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |