The role of cellular quiescence in cancer - beyond a quiet passenger

Autor(es)

Tomasin, Rebeka ; Bruni-Cardoso, Alexandre

• Tipo de documento: Artigo Científico
• Fonte: Journal of Cell Science; v. 135, n. 15, p. 11-pg., 2022-08-01.

Resumo

Quiescence, the ability to temporarily halt proliferation, is a conserved process that initially allowed survival of unicellular organisms during inhospitable times and later contributed to the rise of multicellular organisms, becoming key for cell differentiation, size control and tissue homeostasis. In this Review, we explore the concept of cancer as a disease that involves abnormal regulation of cellular quiescence at every step, from malignant transformation to metastatic outgrowth. Indeed, disrupted quiescence regulation can be linked to each of the so-called 'hallmarks of cancer'. As we argue here, quiescence induction contributes to immune evasion and resistance against cell death. In contrast, loss of quiescence underlies sustained proliferative signalling, evasion of growth suppressors, pro-tumorigenic inflammation, angiogenesis and genomic instability. Finally, both acquisition and loss of quiescence are involved in replicative immortality, metastasis and deregulated cellular energetics. We believe that a viewpoint that considers quiescence abnormalities that occur during oncogenesis might change the way we ask fundamental questions and the experimental approaches we take, potentially contributing to novel discoveries that might help to alter the course of cancer therapy. (AU)

• Processo FAPESP: 19/26767-2 - Regulação da proteostase de MST2 na via Hippo
• Beneficiário: Alexandre Bruni Cardoso
• Modalidade de apoio: Auxílio à Pesquisa - Regular