| Texto completo | |
| Autor(es): |
Franzolin, Marcia Regina
;
Courrol, Daniella dos Santos
;
de Oliveira Silva, Flavia Rodrigues
;
Courrol, Lilia Coronato
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Molecules; v. 27, n. 20, p. 16-pg., 2022-10-01. |
| Resumo | |
The increased number of resistant microbes generates a search for new antibiotic methods. Metallic nanoparticles have emerged as a new platform against several microorganisms. The nanoparticles can damage the bacteria membrane and DNA by oxidative stress. The photoreduction process is a clean and low-cost method for obtaining silver and gold nanoparticles. This work describes two original insights: (1) the use of extracts of leaves and fruits from a Brazilian plant Plinia cauliflora, compared with a well know plant Punica granatum, and (2) the use of phytochemicals as stabilizing agents in the photoreduction process. The prepared nanoparticles were characterized by UV-vis, FTIR, transmission electron microscopy, and Zeta potential. The antimicrobial activity of nanoparticles was obtained with Gram-negative and Gram-positive bacteria, particularly the pathogens Staphylococcus aureus ATCC 25923; Bacillus subtilis ATCC 6633; clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecalis; Escherichia coli ATCC 25922; Escherichia coli O44:H18 EAEC042 (clinical isolate); Klebsiella pneumoniae ATCC 700603, Salmonella Thiphymurium ATCC 10231; Pseudomonas aeruginosa ATCC 27853; and Candida albicans ATCC 10231. Excellent synthesis results were obtained. The AgNPs exhibited antimicrobial activities against Gram-negative and Gram-positive bacteria and yeast (80-100%), better than AuNPs (0-87.92%), and may have the potential to be used as antimicrobial agents. (AU) | |
| Processo FAPESP: | 19/13291-0 - Avaliação do potencial antimicrobiano de nanopartículas de ouro e prata sintetizadas empregando extrato aquoso de Mimusops coriacea |
| Beneficiário: | Marcia Regina Franzolin |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |