| Texto completo | |
| Autor(es): Mostrar menos - |
Goncalves, Guilherme S.
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Correa-Silva, Simone
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Zheng, Yingying
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Avelar, Isabela
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Montenegro, Marilia M.
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Ferreira, Arthur E. F.
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Bain, Vera
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Fink, Thais T.
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Suguita, Priscila
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Astley, Camilla
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Lindoso, Livia
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Martins, Fernanda
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Matsuo, Olivia M.
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Ferreira, Juliana C. O. A.
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Firigato, Isabela
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Goncalves, Fernanda de Toledo
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Pereira, Maria Fernanda B.
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da Silva, Clovis Artur A.
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Carneiro-Sampaio, Magda
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Marques, Heloisa H. S.
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Palmeira, Patricia
Número total de Autores: 21
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| Tipo de documento: | Artigo Científico |
| Fonte: | CYTOKINE; v. 161, p. 12-pg., 2023-01-01. |
| Resumo | |
The exacerbation of the inflammatory response caused by SARS-CoV-2 in adults promotes the production of soluble mediators that could act as diagnostic and prognostic biomarkers for COVID-19. Among the potential biomarkers, the soluble triggering receptor expressed on myeloid cell-1 (sTREM-1) has been described as a predictor of inflammation severity. The aim was to evaluate sTREM-1 and cytokine serum concentrations in pediatric patients during the acute and convalescent phases of COVID-19. This was a prospective study that included 53 children/adolescents with acute COVID-19 (Acute-CoV group); 54 who recovered from COVID-19 (Post-CoV group) and 54 controls (Control group). Preexisting chronic conditions were present in the three groups, which were defined as follows: immunological diseases, neurological disorders, and renal and hepatic failures. The three groups were matched by age, sex, and similar preexisting chronic conditions. No differences in sTREM-1 levels were detected among the groups or when the groups were separately analyzed by preexisting chronic conditions. However, sTREM-1 analysis in the seven multisystemic inflammatory syndrome children (MIS-C) within the Acute-Cov group showed that sTREM-1 concentrations were higher in MIS-C vs non-MIS-C acute patients. Then, the receiver operating curve analysis (ROC) performed with MIS-C acute patients revealed a significant AUC of 0.870, and the sTREM-1 cutoff value of > 5781 pg/mL yielded a sensitivity of 71.4 % and a specificity of 91.3 % for disease severity, and patients with sTREM-1 levels above this cutoff presented an elevated risk for MIS-C development in 22.85-fold (OR = 22.85 [95 % CI 1.64-317.5], p = 0.02). The cytokine analyses in the acute phase revealed that IL-6, IL-8, and IL-10 concentrations were elevated regardless of whether the patient developed MIS-C, and those levels decreased in the convalescent phase, even when compared with controls. Spearman correlation analysis generated positive indexes between sTREM-1 and IL-12 and TNF-alpha concentrations, only within the Acute-CoV group. Our findings revealed that sTREM-1 in pediatric patients has good predictive accuracy as an early screening tool for surveillance of MIS-C cases, even in patients with chronic underlying conditions. (AU) | |
| Processo FAPESP: | 16/06887-5 - Estudo de biomarcadores proteicos e perfil de expressão gênica da via do nf-b na sepse neonatal tardia: valor potencial no diagnóstico e prognóstico |
| Beneficiário: | Patricia Palmeira Daenekas Jorge |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 21/03037-9 - Avaliação dos níveis do TREM-1 solúvel em pacientes pediátricos com COVID-19 e pós-infecção com o vírus SARS-COV-2 tratados no HC-FMUSP |
| Beneficiário: | Guilherme de Souza Gonçalves |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 14/50489-9 - O timo humano: desenvolvimento e doenças |
| Beneficiário: | Magda Maria Sales Carneiro-Sampaio |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |