Clinical, histological, and nanomechanical parameters of implants placed in healthy and metabolically compromised patients

Autor(es)

Granato, Rodrigo ; Bergamo, Edmara T. P. ; Witek, Lukasz ; Bonfante, Estevam A. ; Marin, Charles ; Greenberg, Michael ; Kurgansky, Gregory ; Coelho, Paulo G.

• Tipo de documento: Artigo Científico
• Fonte: Journal of Dentistry; v. 100, p. 8-pg., 2020-09-01.

Resumo

Objectives: To evaluate the clinical outcomes, histological parameters, and bone nanomechanical properties around implants retrieved from healthy and metabolic syndrome (MS) patients. Methods: Twenty-four patients with edentulous mandibles (12/condition), received four implants between the mental foramina. An additional implant prototype was placed for retrieval histology. The following clinical outcomes were evaluated: insertion torque (IT), implant stability quotient (ISQ) values at baseline and after 60 days of healing, and implant survival. The prototype was retrieved after the healing and histologically processed for bone morphometric evaluation of bone-to-implant contact (%BIC) and bone area fraction occupancy (% BAFO), and bone nanoindentation to determine the elastic modulus (Em) and hardness (H). Descriptive statistical procedures and survival tests were used to analyze the data. Results: The final study population was comprised of 10 women and 11 men (similar to 64 years). A total of 105 implants were placed, 21 retrieved for histology. Implant survival rates were similar between groups (> 99 %). Similarly, IT and ISQ analyses showed no significant association with systemic condition (p > 0.216). Histological micrographs depicted similar bone morphology, woven bone, for both conditions. While MS (33 +/- 5.3 %) and healthy (39 +/- 6.5 %) individuals showed no significant difference for %BIC (p = 0.116), significantly higher %BAFO was observed for healthy (45 +/- 4.6 %) relative to MS (30 +/- 3.8 %) (p < 0.001). No significant differences on bone nanomechanical properties was observed (p > 0.804). Conclusions: Although no significant influence on clinical parameters and bone nanomechanical properties was observed, MS significantly reduced bone formation in the peri-implant area in the short-term. Clinical Significance: A lower amount of bone formation in the peri-implant area was observed in comparison to healthy patients, although the other short-term clinical outcomes were not significantly different. Considering the escalating prevalence of MS patients in need for implant treatment, it becomes crucial to understand bone-to implant response to determine the ideal loading time in this population. (AU)

• Processo FAPESP: 12/19078-7 - Desenvolvimento e processamento de compósito de Al2O3-ZrO2 para próteses monolíticas CAD/CAM: efeito do envelhecimento na resistência à flexão biaxial
• Beneficiário: Estevam Augusto Bonfante
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 16/18818-8 - EMU concedido no processo 2012/19078-7: ElectroPuls E3000 Linear-Torsion All-Electric dynamic test instrument package
• Beneficiário: Estevam Augusto Bonfante
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários