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Prevalence and persistence of HPV-16 molecular variants in the anal canal of men: The HIM study

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Goncalves, Milena Giulia ; Ferreira, Matthew Thomas ; Mendoza Lopez, Rossana Veronica ; Ferreira, Silvaneide ; Sirak, Bradley ; Baggio, Maria Luiza ; Lazcano-Ponce, Eduardo ; Nyitray, Alan G. ; Giuliano, Anna R. ; Villa, Luisa L. ; Sichero, Laura ; HIM Study Grp
Número total de Autores: 12
Tipo de documento: Artigo Científico
Fonte: Journal of Clinical Virology; v. 149, p. 7-pg., 2022-03-22.
Resumo

Background: HPV-16 causes approximately 90% of anal canal (AC) cancers worldwide. This study aimed to evaluate the prevalence and persistence of HPV-16 genetic variants in the AC of men from three different countries (Brazil, Mexico and United States) and to further identify sociodemographic and behavioral factors associated with these infections.& nbsp;Methods: Participants from the multinational prospective HPV Infection in Men (HIM) Study who had at least one HPV-16 positive AC swab were included. Characterization into HPV-16 genetic variants was successfully performed by PCR-sequencing in 95.6% (217/227) samples and these were classified into HPV-16 lineages and sublineages.& nbsp;Results: We observed higher prevalence of lineage A variants, mainly from A1 sublineage, in all countries. Non-A lineage variants were mostly detected in men from Brazil, where higher diversity of sublineage variants was detected during follow-up. Compare to men detected with Non-A HPV-16 lineage variants, men infected with lineage A reported a higher lifetime number of female sexual partners. Finally, a significantly higher prevalence of Non-A lineage variants was observed among men who have sex with men (MSM) with a transient HPV-16 AC infection (p = 0.033), but no significant differences regarding variants lineages and persistence status were observed when stratified by country, self-reported ethnicity or age.& nbsp;Conclusions: Our data extend previous reports which indicate that globally HPV-16 variants are unevenly distributed, and contribute further to studies of the natural history of AC HPV infections in men. (AU)

Processo FAPESP: 08/57889-1 - Instituto de Ciência e Tecnologia para o Estudo das Doenças Associadas ao Papilomavírus
Beneficiário:Luisa Lina Villa
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 17/23211-8 - Impacto das variantes genéticas de HPV na persistência da infecção e risco de doença: uma abordagem epidemiológica e funcional
Beneficiário:Laura Cristina Sichero Vettorazzo
Modalidade de apoio: Auxílio à Pesquisa - Temático