| Texto completo | |
| Autor(es): |
Santos, Geovane R.
;
Pinto, Clovis A. L.
;
Prudente, Raphael C. S.
;
Witkin, Steven S.
;
Arandes, Antoni S.
;
Rodrigues, Laura C.
;
Zatz, Mayana
;
Massad, Eduardo
;
Passos, Saulo D.
;
Zika Consortium
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY; v. 41, n. 4, p. 8-pg., 2022-07-01. |
| Resumo | |
In pregnant women, Zika virus (ZIKV) is associated with a congenital syndrome, most frequently involving damage to embryo brain formation and the development of microcephaly. The mechanism(s) by which ZIKV enters the maternal-fetal interface and is transmitted to the fetus remains incompletely determined. We sought to evaluate histologic changes in the placenta of ZIKV-infected pregnant women and to determine if this varied by maternal age. Placental samples were obtained from 66 women, 33 of whom were positive for ZIKV. Histologic evaluations were performed on 4 areas of the placenta: fetal surface, maternal surface, umbilical cord, and membranes. Samples were analyzed by the tissue microarray technique and tested for CD4, CD8, CD20, CD68, FOXP3, and cyclooxygenase-2 expression. Data were evaluated using Fisher exact test. ZIKV infection was more frequent in women less than 18 yr of age (9/11, 81.8%) than in women above 18 yr old (24/55, 43.6%) (P=0.0440). ZIKV detection was associated with neutrophilic chorioamnionitis (P=0.0332) and with septal (P=0.0244) and villous (P=0.0534) calcification. Hofbauer cell hyperplasia (P=0.0260) and cyclooxygenase-2 expression (P=0.0346) were more prevalent in ZIKV-positive women aged 18 yr and below than in the older ZIKV-positive women. ZIKV infection during pregnancy occurs more frequently in adolescents and induces higher rates of damage at the maternal-fetal interface than in older women. (AU) | |
| Processo FAPESP: | 16/08578-0 - Infecção vertical pelo vírus Zika e suas repercussões na área materno-infantil |
| Beneficiário: | Saulo Duarte Passos |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |