Cross-kingdom microbial interactions in dental implant-related infections: is Candida albicans a new villain?

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Souza, Joao G. S. ; Costa, Raphael C. ; Sampaio, Aline A. ; Abdo, Victoria L. ; Nagay, Bruna E. ; Castro, Nidia ; Retamal-Valdes, Belen ; Shibli, Jamil A. ; Feres, Magda ; Barao, Valentim A. R. ; Bertolini, Martinna

• Tipo de documento: Artigo Científico
• Fonte: ISCIENCE; v. 25, n. 4, p. 21-pg., 2022-03-16.

Resumo

Candida albicans, an oral fungal opportunistic pathogen, has shown the ability to colonize implant surfaces and has been frequently isolated from biofilms associated with dental implant-related infections, possibly due to its synergistic interactions with certain oral bacteria. Moreover, evidence suggests that this cross-kingdom interaction on implant can encourage bacterial growth, leading to increased fungal virulence and mucosal damage. However, the role of Candida in implant-related infections has been overlooked and not widely explored or even considered by most microbiological analyses and therapeutic approaches. Thus, we summarized the scientific evidence regarding the ability of C. albicans to colonize implant surfaces, interact in implant-related polymicrobial biofilms, and its possible role in peri-implant infections as far as biologic plausibility. Next, a systematic review of preclinical and clinical studies was conducted to identify the relevance and the gap in the existing literature regarding the role of C. albicans in the pathogenesis of peri-implant infections. (AU)

• Processo FAPESP: 20/05231-4 - Desenvolvimento de um novo hidrogel termosensitivo para liberação controlada de drogas direcionado a prevenção e ao tratamento de inflamações peri-implantares
• Beneficiário: Valentim Adelino Ricardo Barão
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 20/10436-4 - Síntese, caracterização e desempenho biológico de nanopolímeros pH-sensitivos produzidos por impressão molecular para o tratamento das infecções peri-implantares
• Beneficiário: Raphael Cavalcante Costa
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 19/17238-6 - Revestimento antibacteriano com potencial fotocatalítico sob luz visível para implantes dentários: estudos in vitro, in situ e in vivo
• Beneficiário: Bruna Egumi Nagay
• Modalidade de apoio: Bolsas no Brasil - Doutorado