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Dose Response Effect of Photobiomodulation on Hemodynamic Responses and Glucose Levels in Men with Type 2 Diabetes: A Randomized, Crossover, Double-Blind, Sham-Controlled Trial

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Linares, Stephanie N. ; Beltrame, Thomas ; Galdino, Gabriela A. M. ; Frade, Maria Cecilia M. ; Milan-Mattos, Juliana C. ; Gois, Mariana O. ; Borghi-Silva, Audrey ; de Biase, Priscila F. ; Manchado-Gobatto, Fulvia B. ; Bagnato, Vanderlei S. ; Parizotto, Nivaldo A. ; Ferraresi, Cleber ; Catai, Aparecida M.
Número total de Autores: 13
Tipo de documento: Artigo Científico
Fonte: PHOTONICS; v. 9, n. 7, p. 15-pg., 2022-07-01.
Resumo

This study verifies the acute dose response effect of photobiomodulation (PBM) by light emitting diodes (LEDs) on hemodynamic and metabolic responses in individuals with type 2 diabetes mellitus (T2DM). Thirteen participants with T2DM (age 52 +/- 7 years) received PBM by a light-emitting diode array (50 GaAIAs LEDs, 850 +/- 20 nm, 75 mW per diode) on the rectus and oblique abdomen, quadriceps femoris, triceps surae, and hamstring muscle areas, bilaterally, using different energy treatments (sham, 75, 150, 300, 450, and 600 Joules) in random order with a washout of at least 15 days apart. The PBM by LEDs statistically decreased plasma glucose levels (primary outcome) in 15 min after application of the 75 and 450 J irradiation protocol, reduced blood lactate levels 15 min after application of the 75, 450, and 600 J irradiation protocol, increased cardiac output ((Q)over dot) and cardiac index (CI) in the 1st minute after application of the 75 and 300 J irradiation protocol, and reduced (Q)over dot and heart rate (HR) in the 15 min after application of the 300 J and 600 J irradiation protocol, respectively. For hemodynamic variables, including (Q)over dot, total peripheral resistance (TPR), and HR, we observed that the ideal therapeutic window ranged between 75 and 300 J, while for metabolic variables, glucose and lactate, the variation was between 450 and 600 J. (AU)

Processo FAPESP: 17/09639-5 - Explorando técnicas de aprendizado de máquina para a modelagem do sistema aeróbio e suas aplicações em programas de reabilitação cardiorrespiratória
Beneficiário:Thomas Beltrame
Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 13/07953-3 - Avaliação do efeito agudo da fototerapia por meio de diodos emissores de luz (LEDs) na cinética do consumo de oxigênio muscular e pulmonar em pacientes com diabetes mellitus
Beneficiário:Aparecida Maria Catai
Modalidade de apoio: Auxílio à Pesquisa - Regular