Extracellular Vesicles in Trypanosoma cruzi Infection: Immunomodulatory Effects and Future Perspectives as Potential Control Tools against Chagas Disease

Autor(es)

Cortes-Serra, Nuria ; Gualdron-Lopez, Melisa ; Pinazo, Maria-Jesus ; Torrecilhas, Ana Claudia ; Fernandez-Becerra, Carmen

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF IMMUNOLOGY RESEARCH; v. 2022, p. 11-pg., 2022-08-17.

Resumo

Chagas disease, caused by the protozoa parasite Trypanosoma cruzi, is a neglected tropical disease and a major public health problem affecting more than 6 million people worldwide. Many challenges remain in the quest to control Chagas disease: the diagnosis presents several limitations and the two available treatments cause several side effects, presenting limited efficacy during the chronic phase of the disease. In addition, there are no preventive vaccines or biomarkers of therapeutic response or disease outcome. Trypomastigote form and T. cruzi-infected cells release extracellular vesicles (EVs), which are involved in cell-to-cell communication and can modulate the host immune response. Importantly, EVs have been described as promising tools for the development of new therapeutic strategies, such as vaccines, and for the discovery of new biomarkers. Here, we review and discuss the role of EVs secreted during T. cruzi infection and their immunomodulatory properties. Finally, we briefly describe their potential for biomarker discovery and future perspectives as vaccine development tools for Chagas Disease. (AU)

• Processo FAPESP: 20/07870-4 - Mecanismos de adaptação de tripanossomatídeos ao hospedeiro através de controle da transcrição, síntese proteica e secreção de vesículas extracelulares
• Beneficiário: Ana Claudia Trocoli Torrecilhas
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/15909-0 - Estudos do mecanismos de secreção de vesículas extracelulares por protozoários parasitas
• Beneficiário: Sergio Schenkman
• Modalidade de apoio: Auxílio à Pesquisa - Regular