Curcumin-Loaded Mesoporous Silica Nanoparticles Dispersed in Thermo-Responsive Hydrogel as Potential Alzheimer Disease Therapy

Autor(es)

Ribeiro, Tais de Cassia ; Sabio, Rafael Miguel ; Luiz, Marcela Tavares ; de Souza, Lucas Canto ; Fonseca-Santos, Bruno ; Cides da Silva, Luis Carlos ; de Abreu Fantini, Marcia Carvalho ; Planeta, Cleopatra da Silva ; Chorilli, Marlus

• Tipo de documento: Artigo Científico
• Fonte: PHARMACEUTICS; v. 14, n. 9, p. 19-pg., 2022-09-01.

Resumo

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive and behavioral impairment. Curcumin-loaded mesoporous silica nanoparticles (MSN-CCM) can overcome the drawbacks related to the free curcumin (CCM) clinical application, such as water insolubility and low bioavailability, besides acting over the main causes associated to AD. A thermo-responsive hydrogel is an interesting approach for facilitating the administration of the nanosystem via a nasal route, as well as for overcoming mucociliary clearance mechanisms. In light of this, MSN-CCM were dispersed in the hydrogel and evaluated through in vitro and in vivo assays. The MSNs and MSN-CCM were successfully characterized by physicochemical analysis and a high value of the CCM encapsulation efficiency (EE%, 87.70 +/- 0.05) was achieved. The designed thermo-responsive hydrogel (HG) was characterized by rheology, texture profile analysis, and ex vivo mucoadhesion, showing excellent mechanical and mucoadhesive properties. Ex vivo permeation studies of MSN-CCM and HG@MSN-CCM showed high permeation values (12.46 +/- 1.08 and 28.40 +/- 1.88 mu g cm(-2) of CCM, respectively) in porcine nasal mucosa. In vivo studies performed in a streptozotocin-induced AD model confirmed that HG@MSN-CCM reverted the cognitive deficit in mice, acting as a potential formulation in the treatment of AD. (AU)

• Processo FAPESP: 19/19228-8 - Avaliação do potencial de curcumina incorporada em nanopartículas de sílica mesoporosas dispersas em hidrogéis termorresponsivos no tratamento da Doença de Alzheimer
• Beneficiário: Tais de Cassia Ribeiro
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 18/25377-3 - Avaliação do potencial de nanopartículas de sílica mesoporosas funcionalizadas com cetuximabe para veiculação de docetaxel no tratamento do câncer de próstata.
• Beneficiário: Rafael Miguel Sábio
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Temático