| Texto completo | |
| Autor(es): |
Clasen, Milan A.
;
Kurt, Louise U.
;
Santos, Marlon D. M.
;
Lima, Diogo B.
;
Liu, Fan
;
Gozzo, Fabio C.
;
Barbosa, Valmir C.
;
Carvalho, Paulo C.
Número total de Autores: 8
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Bioinformatics; v. 38, n. 22, p. 2-pg., 2022-09-21. |
| Resumo | |
Motivation Confident deconvolution of proteomic spectra is critical for several applications such as de novo sequencing, cross-linking mass spectrometry and handling chimeric mass spectra. Results In general, all deconvolution algorithms may eventually report mass peaks that are not compatible with the chemical formula of any peptide. We show how to remove these artifacts by considering their mass defects. We introduce Y.A.D.A. 3.0, a fast deconvolution algorithm that can remove peaks with unacceptable mass defects. Our approach is effective for polypeptides with less than 10 kDa, and its essence can be easily incorporated into any deconvolution algorithm. (AU) | |
| Processo FAPESP: | 14/50867-3 - INCT 2014: Instituto Nacional de Ciência e Tecnologia de Bioanalítica |
| Beneficiário: | Marco Aurelio Zezzi Arruda |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 14/17264-3 - Novas fronteiras em proteômica estrutural: caracterizando estruturas de proteínas e complexos proteicos por espectrometria de massas |
| Beneficiário: | Fabio Cesar Gozzo |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |