| Texto completo | |
| Autor(es): |
Cardoso, Fabrizio dos Santos
;
Salehpour, Farzad
;
Coimbra, Norberto Cysne
;
Gonzalez-Lima, Francisco
;
Gomes da Silva, Sergio
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | FRONTIERS IN NEUROSCIENCE; v. 16, p. 13-pg., 2022-09-20. |
| Resumo | |
Background: Neuroinflammation is a response that involves different cell lineages of the central nervous system, such as neurons and glial cells. Among the non-pharmacological interventions for neuroinflammation, photobiomodulation (PBM) is gaining prominence because of its beneficial effects found in experimental brain research. We systematically reviewed the effects of PBM on laboratory animal models, specially to investigate potential benefits of PBM as an efficient anti-inflammatory therapy.Methods: We conducted a systematic search on the bibliographic databases (PubMed and ScienceDirect) with the keywords based on MeSH terms: photobiomodulation, low-level laser therapy, brain, neuroinflammation, inflammation, cytokine, and microglia. Data search was limited from 2009 to June 2022. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. The initial systematic search identified 140 articles. Among them, 54 articles were removed for duplication and 59 articles by screening. Therefore, 27 studies met the inclusion criteria.Results: The studies showed that PBM has anti-inflammatory properties in several conditions, such as traumatic brain injury, edema formation and hyperalgesia, ischemia, neurodegenerative conditions, aging, epilepsy, depression, and spinal cord injury.Conclusion: Taken together, these results indicate that transcranial PBM therapy is a promising strategy to treat brain pathological conditions induced by neuroinflammation. (AU) | |
| Processo FAPESP: | 21/06473-4 - Potencial terapêutico da fotobiomodulação em ratos com Epilepsia: análise da frequência de crises epilépticas, desempenho cognitivo, e perfil metabolômico cerebral |
| Beneficiário: | Fabrízio dos Santos Cardoso |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 20/15050-7 - Estudo do papel da sinalização endocanabinoide e endovaniloide no paleoestriado, na atividade do duplo elo conectivo GABAérgico neoestriado-pálido-nigro-tectal durante a organização do medo instintivo de animais confrontados com serpentes |
| Beneficiário: | Norberto Cysne Coimbra |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 17/16443-0 - Potencial terapêutico do laser de baixa intensidade no cérebro de ratos idosos |
| Beneficiário: | Fabrízio dos Santos Cardoso |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |