Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses

Autor(es)

Gobira, P. H. ; Joca, S. R. ; Moreira, F. A.

• Tipo de documento: Artigo Científico
• Fonte: ACTA NEUROPSYCHIATRICA; v. N/A, p. 11-pg., 2022-08-22.

Resumo

Addiction to psychostimulant drugs, such as cocaine, D-amphetamine, and methamphetamine, is a public health issue that substantially contributes to the global burden of disease. Psychostimulant drugs promote an increase in dopamine levels within the mesocorticolimbic system, which is central to the rewarding properties of such drugs. Cannabinoid receptors (CB1R and CB2R) are expressed in the main areas of this system and implicated in the neuronal mechanisms underlying the rewarding effect of psychostimulant drugs. Here, we reviewed studies focusing on pharmacological intervention targeting cannabinoid CB1R and CB2R and their interaction in the modulation of psychostimulant responses. (AU)

• Processo FAPESP: 17/24304-0 - Novas perspectivas no emprego de fármacos que modificam neurotransmissores atípicos no tratamento de transtornos neuropsiquiátricos
• Beneficiário: Francisco Silveira Guimaraes
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/19284-0 - Envolvimento da acetilação de histonas na modulação da vulnerabilidade aos efeitos da cocaína induzida pela exposição a canabinoides durante a adolescência
• Beneficiário: Pedro Henrique Gobira Nunes
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado