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Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy

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Autor(es):
Moresi, Viviana ; Renzini, Alessandra ; Cavioli, Giorgia ; Seelaender, Marilia ; Coletti, Dario ; Gigli, Giuseppe ; Cedola, Alessia
Número total de Autores: 7
Tipo de documento: Artigo Científico
Fonte: METABOLITES; v. 12, n. 11, p. 24-pg., 2022-11-01.
Resumo

Neurogenic muscle atrophy is a debilitating condition that occurs from nerve trauma in association with diseases or during aging, leading to reduced interaction between motoneurons and skeletal fibers. Current therapeutic approaches aiming at preserving muscle mass in a scenario of decreased nervous input include physical activity and employment of drugs that slow down the progression of the condition yet provide no concrete resolution. Nutritional support appears as a precious tool, adding to the success of personalized medicine, and could thus play a relevant part in mitigating neurogenic muscle atrophy. We herein summarize the molecular pathways triggered by denervation of the skeletal muscle that could be affected by functional nutrients. In this narrative review, we examine and discuss studies pertaining to the use of functional ingredients to counteract neurogenic muscle atrophy, focusing on their preventive or curative means of action within the skeletal muscle. We reviewed experimental models of denervation in rodents and in amyotrophic lateral sclerosis, as well as that caused by aging, considering the knowledge generated with use of animal experimental models and, also, from human studies. (AU)

Processo FAPESP: 12/50079-0 - Inflamação sistêmica em pacientes com caquexia associada ao câncer: mecanismos e estratégias terapêuticas, uma abordagem em medicina translacional
Beneficiário:Marilia Cerqueira Leite Seelaender
Modalidade de apoio: Auxílio à Pesquisa - Temático
Processo FAPESP: 20/07765-6 - Tempestade de citocinas no paciente de covid-19: contribuição do tecido adiposo
Beneficiário:Marilia Cerqueira Leite Seelaender
Modalidade de apoio: Auxílio à Pesquisa - Regular