| Texto completo | |
| Autor(es): |
de Alencar, Severino Matias
;
Sartori, Alan Giovanini de Oliveira
;
Dag, Damla
;
Batista, Pollyanna Souza
;
Rosalen, Pedro Luiz
;
Ikegaki, Masaharu
;
Kong, Fanbin
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Food Chemistry; v. 411, p. 9-pg., 2023-01-19. |
| Resumo | |
The objectives were to investigate the effect of dynamic gastrointestinal digestion/Caco-2 cell transport on active compounds stability and antioxidant/anti-inflammatory activities of the ethanolic extract of Brazilian red propolis (EEBRP), whether encapsulated or not; and the in vivo acute toxicity of the EEBRP after digestion. Eight isoflavonoids, one flavanone, and one chalcone were identified by HPLC-ESI-QTOF-MS, and quantified by HPLCPDA. Bioaccessibility was higher for the encapsulated EEBRP (21.4%-57.6%) than for the nonencapsulated (19.3%-30.2%). Conversely, the Caco-2 cell transport was higher for the nonencapsulated EEBRP. Similarly, the nonencapsulated EEBRP showed higher ability to scavenge reactive oxygen species, which was especially attributed to calycosin, and to decrease NF-kappa B activation, and the levels of TNF-alpha and CXCL2/MIP-2 after Caco-2 cell transport. Hence, there is an indication that EEBRP is a promising alternative dietary source of bioavailable isoflavonoids. Further studies on encapsulation should be encouraged to improve bioactivity, and expand its food applications. (AU) | |
| Processo FAPESP: | 19/11248-0 - Produção de microcápsulas de própolis vermelha brasileira para uso como conservante natural e desenvolvimento de alimentos funcionais: caracterização, bioacessibilidade e transporte epitelial através de células Caco-2 |
| Beneficiário: | Severino Matias de Alencar |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 19/17426-7 - Padrão de isoflavonoides da própolis vermelha brasileira após digestão gastrintestinal dinâmica e transporte por meio de células Caco-2 |
| Beneficiário: | Severino Matias de Alencar |
| Modalidade de apoio: | Bolsas no Exterior - Pesquisa |