| Texto completo | |
| Autor(es): |
de Oliveira, Joseana
;
Denadai, Marina B.
;
Costa, Diego L.
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ANTIOXIDANTS; v. 11, n. 5, p. 19-pg., 2022-05-01. |
| Resumo | |
Heme oxygenase-1 (HO-1) is an enzyme that catalyzes the degradation of heme, releasing equimolar amounts of carbon monoxide (CO), biliverdin (BV), and iron. The anti-inflammatory and antioxidant properties of HO-1 activity are conferred in part by the release of CO and BV and are extensively characterized. However, iron constitutes an important product of HO-1 activity involved in the regulation of several cellular biological processes. The macrophage-mediated recycling of heme molecules, in particular those contained in hemoglobin, constitutes the major mechanism through which living organisms acquire iron. This process is finely regulated by the activities of HO-1 and of the iron exporter protein ferroportin. The expression of both proteins can be induced or suppressed in response to pro- and anti-inflammatory stimuli in macrophages from different tissues, which alters the intracellular iron concentrations of these cells. As we discuss in this review article, changes in intracellular iron levels play important roles in the regulation of cellular oxidation reactions as well as in the transcriptional and translational regulation of the expression of proteins related to inflammation and immune responses, and therefore, iron metabolism represents a potential target for the development of novel therapeutic strategies focused on the modulation of immunity and inflammation. (AU) | |
| Processo FAPESP: | 20/10321-2 - Treinamento em técnicas laboratoriais, bioterismo, criação e genotipagem de linhagens de camundongos transgênicos com deficiência genética condicional |
| Beneficiário: | Joseana de Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Programa Capacitação - Treinamento Técnico |
| Processo FAPESP: | 21/04028-3 - Estudo sobre a imunomodulação da expressão de ferroportina e homeostasia de ferro em leucócitos mieloides e suas consequências para patogênese da infecção por Mycobacterium tuberculosis |
| Beneficiário: | Marina Bonifácio Denadai |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 19/25770-0 - Imunomodulação da homeostasia de ferro e regulação da via de sinalização de receptores tirosina quinase TAM durante a Infecção por Mycobacterium tuberculosis: alvos para desenvolvimento de terapias imunofarmacológicas direcionadas ao hospedeiro |
| Beneficiário: | Diego Luís Costa |
| Modalidade de apoio: | Bolsas no Brasil - Jovens Pesquisadores |