Depression, temporomandibular disorders, and genetic polymorphisms inIL6impact on oral health-related quality of life in patients requiring orthognathic surgery

Autor(es)

Sebastiani, Aline Monise ; dos Santos, Katheleen Miranda ; Cavalcante, Rafael Correia ; Petinati, Maria Fernanda Pivetta ; Signorini, Luciana ; Alves Antunes, Livia Azeredo ; Barbosa Rebellato, Nelson Luis ; Kuechler, Erika Calvano ; Scariot, Rafaela

• Tipo de documento: Artigo Científico
• Fonte: QUALITY OF LIFE RESEARCH; v. 29, n. 12, p. 9-pg., 2020-07-14.

Resumo

Purpose To assess oral health-related quality of life (OHRQoL) in patients requiring orthognathic surgery, and evaluate if depression, temporomandibular disorders (TMD), and genetic polymorphisms ininterleukin-6(IL6) influence their OHRQoL. Methods A total of 132 individuals included in three different groups. Two groups were composed by patients with dentofacial deformity (DFD) Class II (n = 44) or Class III (n = 44) malocclusions, requiring orthognathic surgery. The control group (n = 44) included individuals without DFD. Patients from all groups were evaluated in preoperative appointments to assessOHRQoL, TMD, and genetic polymorphisms inIL6. OHRQoL was assessed using the 14-item Oral Health Impact Profile (OHIP-14). TMD and depression were assessed using Research Diagnostic Criteria for Temporomandibular Disorders protocol. The genetic polymorphismsrs1800795andrs1800796inIL6were assessed through genomic DNA using real-time polymerase chain reaction. Results OHIP-14 scores were increased in patients with depression, myofascial pain, and inflammatory temporomandibular joint alterations in the right side, regardless of sex and DFD group. Individual homozygous CC inrs1800795had increased values in domains "social disability" and "handicap" of the OHIP-14 compared with those who were homozygous GG. Individual heterozygous CG in thers1800796demonstrated increased values in domain "psychological discomfort" compared with those homozygous for CC and GG. Conclusion In individuals requiring orthognathic surgery, depression, TMD, and genetic polymorphisms inIL6contribute to negative impact on OHRQoL. These physical and emotional conditions, together with biological pathways, should receive more attention in treatment plans, in order to improve the patients' quality of life. (AU)

• Processo FAPESP: 16/08149-1 - Avaliação do papel do estrógeno nos tecidos dentofaciais
• Beneficiário: Erika Calvano Kuchler
• Modalidade de apoio: Bolsas no Brasil - Jovens Pesquisadores