The impact of radiation caries on morbidity and mortality outcomes of head and neck squamous cell carcinoma patients

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Palmier, Natalia Rangel ; Prado-Ribeiro, Ana Carolina ; Mariz, Bruno Augusto Linhares Almeida ; Rodrigues-Oliveira, Leticia ; Paglioni, Mariana de Pauli ; Napimoga, Juliana Trindade Clemente ; Pedroso, Caique Mariano ; Morais-Faria, Karina ; de Oliveira, Maria Cecilia Querido ; Vechiato-Filho, Aljomar Jose ; Brandao, Thais Bianca ; Santos-Silva, Alan Roger

• Tipo de documento: Artigo Científico
• Fonte: SPECIAL CARE IN DENTISTRY; v. N/A, p. 12-pg., 2023-03-05.

Resumo

AimsRadiation caries (RC) is a highly prevalent and chronic complication of head and neck radiotherapy (HNRT) and presents a challenge for clinicians and patients. The present study aimed to assess the impact of RC on the morbidity and mortality outcomes of head and neck squamous cell carcinoma (HNSCC) patients. Methods and ResultsPatients were divided into three groups: (1) RC (n = 20), (2) control (n = 20), and (3) edentulous (n = 20). Information regarding the number of appointments, dental procedures, osteoradionecrosis (ORN), prescriptions, and hospital admissions were collected. Mortality outcomes were assessed through disease-free survival (DFS) and overall survival (OS) rates. RC patients required more dental appointments (p < .001), restorations (p < .001), extractions (p = .001), and antibiotic and analgesic prescriptions (p < .001). Kaplan-Meier subgroup analyses showed a significantly increased risk of ORN in RC compared to edentulous patients (p = .015). RC patients presented lower DFS rates (43.2 months) than the control and edentulous groups (55.4 and 56.1 months, respectively). ConclusionsRC impacts morbidity outcomes among cancer survivors due to increased demand for medication prescriptions, multiple specialized dental appointments, invasive surgical treatments, increased risk of ORN, and increased need for hospital admissions. (AU)

• Processo FAPESP: 18/04657-8 - Proteínas salivares candidatas a marcadores de toxicidade bucal associada à radioterapia
• Beneficiário: Natália Rangel Palmier
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 12/06138-1 - Estudo prospectivo da incidência de trismo induzido por radioterapia em pacientes com carcinoma espinocelular de boca
• Beneficiário: Ana Carolina Prado Ribeiro e Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/02233-6 - Segurança oncológica no uso da fotobiomodulação intraoral e extraoral em pacientes com carcinoma espinocelular de cavidade oral e orofaringe
• Beneficiário: Alan Roger dos Santos Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/18402-8 - Avaliação dos efeitos diretos da radiação sobre o esmalte, a dentina e a polpa dental de pacientes com câncer de cabeça e pescoço
• Beneficiário: Alan Roger dos Santos Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 16/22862-2 - Impacto da idade sobre as toxicidades bucais induzidas pela radioterapia em pacientes jovens com câncer de boca
• Beneficiário: Jaqueline de Lima Correia
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica