Abdominal adiposity as a prognosis biomarker of clinical outcome in metastatic colorectal cancer

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Oikawa, Karina Hiromoto ; Juliani, Fabiana Lascala ; Carrilho, Larissa Ariel Oliveira ; Pozzuto, Lara ; Padilha, Daniela Morais de Hollanda ; Silveira, Marina Nogueira ; Costa, Felipe Osorio ; Macedo, Ligia Traldi ; da Cunha, Ademar Dantas ; Mendes, Maria Carolina Santos ; Carvalheira, Jose Barreto Campello

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION; v. 107, p. 7-pg., 2022-12-21.

Resumo

Objectives: Adipose tissue distribution and radiodensity are associated with prognosis in many types of can-cer. However, the roles of adipose tissue distribution and radiodensity in patients with metastatic colorectal cancer (mCRC) remain unclear. The aim of this study was to assess the prognostic effect of adiposity and adi-pose tissue radiodensities in patients with mCRC. Methods: Patients with mCRC who received first-line palliative chemotherapy and had a computed tomogra-phy (CT) scan at the third lumbar vertebra (L3) level, admitted between January 2010 and December 2018, were sequentially enrolled. Body composition was assessed using CT-derived measurements. Univariate and multivariate logistic regression analyses and Kaplan-Meier curves were used to determine prognostic values. Results: The study included 237 patients. Cox analyses demonstrated that high subcutaneous adipose tissue (SAT) index was associated with a lower risk for death (hazard ratio [HR], 0.51; 95% confidence interval [CI], 0.29-0.88; Ptrend < 0.025). There was no significant association between visceral adipose tissue (VAT) index tertiles and overall survival. However, high VAT and SAT radiodensities were significantly associated with increased mortality (HR, 1.80; 95% CI, 1.12-2.89; Ptrend < 0.030 and HR, 1.85; 95% CI, 1.19-2.86; Ptrend < 0.021, respectively). Conclusions: A higher SAT index in patients with mCRC was associated with a favorable overall survival out-come, whereas higher SAT and VAT radiodensities were associated with an increased risk for death, support-ing that early nutritional intervention may improve mCRC prognosis. (c) 2022 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 18/23428-0 - Caracterização do perfil metabólico de pacientes com câncer colorretal que diferem quanto à sarcopenia
• Beneficiário: José Barreto Campello Carvalheira
• Modalidade de apoio: Auxílio à Pesquisa - Regular