Human leptospirosis: In search for a better vaccine

Autor(es)

Azevedo, Isabela Resende ; Amamura, Thais Akemi ; Isaac, Lourdes

• Tipo de documento: Artigo Científico
• Fonte: Scandinavian Journal of Immunology; v. 98, n. 5, p. 21-pg., 2023-08-07.

Resumo

Leptospirosis is a neglected disease caused by bacteria of the genus Leptospira and is more prevalent in tropical and subtropical countries. This pathogen infects humans and other animals, responsible for the most widespread zoonosis in the world, estimated to be responsible for 60 000 deaths and 1 million cases per year. To date, commercial vaccines against human leptospirosis are available only in some countries such as Japan, China, Cuba and France. These vaccines prepared with inactivated Leptospira (bacterins) induce a short-term and serovar-specific immune response, with strong adverse side effects. To circumvent these limitations, several research groups are investigating new experimental vaccines in order to ensure that they are safe, efficient, and protect against several pathogenic Leptospira serovars, inducing sterilizing immunity. Most of these protocols use attenuated cultures, preparations after LPS removal, recombinant proteins or DNA from pathogenic Leptospira spp. The aim of this review was to highlight several promising vaccine candidates, considering their immunogenicity, presence in different pathogenic Leptospira serovars, their role in virulence or immune evasion and other factors. (AU)

• Processo FAPESP: 20/16104-3 - Avaliação da metaloprotease papalisina de leptospiras patogênicas como antígeno vacinal
• Beneficiário: Isabela Resende Azevedo
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 17/10208-9 - Avaliação da atividade proteolítica de proteases secretadas por leptospiras patogênicas na fagocitose por fagócitos humanos e murinos
• Beneficiário: Thais Akemi Amamura
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 17/12924-3 - Etiopatogênese da Leptospirose: contribuição do sistema complemento in vivo e in vitro para o controle da infecção e desencadeamento da resposta inflamatória tecidual: estudo de polimorfismos de genes do sistema complemento em pacientes com Leptospirose
• Beneficiário: Lourdes Isaac
• Modalidade de apoio: Auxílio à Pesquisa - Temático