Exosomes as a Nano-Carrier for Chemotherapeutics: A New Era of Oncology

Autor(es)

Araldi, Rodrigo Pinheiro ; Delvalle, Denis Adrian ; da Costa, Vitor Rodrigues ; Alievi, Anderson Lucas ; Teixeira, Michelli Ramires ; Pinto, Joao Rafael Dias ; Kerkis, Irina

• Tipo de documento: Artigo Científico
• Fonte: CELLS; v. 12, n. 17, p. 22-pg., 2023-09-01.

Resumo

Despite the considerable advancements in oncology, cancer remains one of the leading causes of death worldwide. Drug resistance mechanisms acquired by cancer cells and inefficient drug delivery limit the therapeutic efficacy of available chemotherapeutics drugs. However, studies have demonstrated that nano-drug carriers (NDCs) can overcome these limitations. In this sense, exosomes emerge as potential candidates for NDCs. This is because exosomes have better organotropism, homing capacity, cellular uptake, and cargo release ability than synthetic NDCs. In addition, exosomes can serve as NDCs for both hydrophilic and hydrophobic chemotherapeutic drugs. Thus, this review aimed to summarize the latest advances in cell-free therapy, describing how the exosomes can contribute to each step of the carcinogenesis process and discussing how these nanosized vesicles could be explored as nano-drug carriers for chemotherapeutics. (AU)

• Processo FAPESP: 23/06116-2 - Desenvolvimento de um modelo analítico-preditivo baseado na integração de inteligência artificial e dados transcriptômicos aplicado à identificação de alvos moleculares de interesse (bio)farmacêutico
• Beneficiário: Rodrigo Pinheiro Araldi
• Modalidade de apoio: Auxílio à Pesquisa - Pesquisa Inovativa em Pequenas Empresas - PIPE