| Texto completo | |
| Autor(es): |
de Lima, Lucas F.
;
Ferreira, Andre L.
;
Ranjan, Ishani
;
Collman, Ronald G.
;
de Araujo, William R.
;
de la Fuente-Nunez, Cesar
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CELL REPORTS PHYSICAL SCIENCE; v. 4, n. 8, p. 19-pg., 2023-08-16. |
| Resumo | |
COVID-19 has led to over 6.8 million deaths worldwide and con-tinues to affect millions of people, primarily in low-income countries and communities with low vaccination coverage. Low-cost and rapid response technologies that enable accurate, frequent testing of se-vere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vari-ants are crucial for outbreak prevention and infectious disease con-trol. Here we produce and characterize cellulose fibers naturally generated by the bacterium Gluconacetobacter hansenii as an alter-native biodegradable substrate for manufacturing an eco-friendly diagnostic test for COVID-19. Using this green technology, we describe a novel and label-free potentiometric diagnostic test that can detect SARS-CoV-2 within 10 min and costs US$3.50 per unit. The test has bacterial cellulose (BC) as its substrate and a carbon -based electrode modified with graphene oxide and the human angiotensin-converting enzyme-2 (ACE2) as its receptor. Our device accurately and precisely detects emerging SARS-CoV-2 variants and demonstrates exceptional sensitivity, specificity, and accuracy for tested clinical nasopharyngeal/oropharyngeal (NP/OP) samples. (AU) | |
| Processo FAPESP: | 22/03250-7 - Desenvolvimento de biossensores portáteis e acessíveis para diagnósticos clínicos de infecções bacterianas e virais |
| Beneficiário: | William Reis de Araujo |
| Modalidade de apoio: | Auxílio à Pesquisa - Projeto Inicial |