| Texto completo | |
| Autor(es): |
Meyfarth, Sandra Regina Santos
;
Antunes, Livia Azeredo Alves
;
da Silva Tavares, Jhenyfer
;
Guimaraes, Ludmila da Silva
;
da Silva, Erlange Andrade Borges
;
Baratto-Filho, Flares
;
Kuechler, Erika Calvano
;
Silva-Sousa, Alice Correa
;
Sousa-Neto, Manoel Damiao
;
Antunes, Leonardo Santos
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | AUSTRALIAN ENDODONTIC JOURNAL; v. N/A, p. 9-pg., 2023-09-19. |
| Resumo | |
The aim of this study was to investigate whether there is an association between inducible in single nucleotide polymorphisms in nitric oxide synthase (rs2297518 and rs2779249) and persistent apical periodontitis. A total of 291 Brazilian subjects were included: 125 with signs/symptoms of persistent apical periodontitis and 166 with root canal-treated teeth exhibiting healthy perirradicular tissues. Endodontically treated patients were followed up after 1 year. The two single nucleotide polymorphisms in nitric oxide synthase were analysed using real-time polymerase chain reaction. Chi-square test and odds ratio with 95% confidence intervals were performed to compare genotype distributions between 'healed' and 'persistent apical periodontitis' groups (p < 0.05). Logistic regression analysis was used to evaluate SNP-SNP interactions. The allele and genotype distributions for the polymorphisms between the persistent apical periodontitis and healed groups were not statistically significant (p > 0.05). In the logistic regression analysis, the polymorphisms were not associated with persistent apical periodontitis and SNP-SNP interactions. (AU) | |
| Processo FAPESP: | 18/21130-3 - Aspectos moleculares da resposta do hospedeiro na periodontite apical persistente |
| Beneficiário: | Manoel Damiao de Sousa Neto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |