Photodegradation in the infrared region of indocyanine green in aqueous solution

Autor(es)

Diaz Tovar, Johan Sebastian ; Kassab, Giulia ; Inada, Natalia Mayumi ; Bagnato, Vanderlei Salvador ; Kurachi, Cristina ; IEEE

• Tipo de documento: Artigo Científico
• Fonte: 2019 SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE (SBFOTON IOPC); v. N/A, p. 5-pg., 2019-01-01.

Resumo

Indocyanine green (ICG) is a water soluble anionic tricarbocyanine dye which has been widely used for biological applications. The photodegradation and aggregation of ICG were studied in aqueous solution by absorbance spectrum measurements. Two excitation wavelengths were used: 780 and 808 nm. The photodegradation analysis was performed based on the number of absorbed photons and rate equations of the electronic excited states. The aggregation effect is influenced by the solvent medium. A third emission band at 640 nm, observed when in PBS solution, could be observed, associated with a trimeric band. The degradation of the aggregated forms does not follow the Beer-Lambert law. The photodegradation rates were distinct between the two excitation wavelengths, showing distinct photodegradation behaviors. (AU)

• Processo FAPESP: 18/18188-0 - Inativação fotodinâmica da Pneumonia Bacteriana utilizando nebulização do fotossensibilizador e iluminação extracorpórea
• Beneficiário: Giulia Kassab
• Modalidade de apoio: Bolsas no Brasil - Doutorado