Precision medicine for prostate cancer-improved outcome prediction for low-intermediate risk disease using a six-gene copy number alteration classifier

Autor(es)

Lautert-Dutra, William ; dos Reis, Rodolfo Borges ; Squire, Jeremy A.

• Tipo de documento: Artigo Científico
• Fonte: BRITISH JOURNAL OF CANCER; v. 128, n. 12, p. 2-pg., 2023-04-29.

Resumo

A multiplex 6-gene copy number classifier was used to distinguish between low- or intermediate-risk prostate cancer patients. The study analysed a cohort of 448 patients and previously published datasets from radical prostatectomies. The classifier performs better than conventional stratification methods, is low cost, and can be performed easily in clinical laboratories. (AU)

• Processo FAPESP: 19/22912-8 - Caracterização dos mecanismos genéticos que levam à evasão imunológica no microambiente tumoral do Câncer de Próstata
• Beneficiário: Jeremy Andrew Squire
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 21/12271-5 - O impacto da mutação no gene CDK12 na resposta imune do câncer de próstata
• Beneficiário: William Lautert Dutra
• Modalidade de apoio: Bolsas no Brasil - Mestrado